(R)-5-硝基-3-(1-(2-(三氟甲基)苯基)乙氧基)噻吩-2-羧酸甲酯合成路线 （共 2 条）
反应条件
1: With polymer supported triphenylphosphine; diethylazodicarboxylate in dichloromethane
T=0 - 20°C; 21.25 h;
2: With hydrogenchloride in 1,4-dioxane
T=20°C; 3 h;
参考文献
Hornberger, Keith R.; Badiang, Jennifer G.; Salovich, James M.; Kuntz, Kevin W.; Emmitte, Kyle A.; Cheung, Mui
Tetrahedron Letters, 2008 , vol. 49, # 44 p. 6348 - 6351
反应条件
1: With iron; acetic acid
T=50 - 60°C; 2.5 h;
2: With sodium hydroxide; sodium hydrogencarbonate in water
参考文献
Kuntz, Kevin; Emmitte, Kyle Allen; Rheault, Tara Renae; Smith, Stephon; Hornberger, Keith; Dickson, Hamilton; Cheung, Mui
Patent: US2008/300247 A1, 2008 ;
Location in patent: Page/Page column 53-54 ;
