2-氯-1-(2,3-二氟苯基)乙酮合成路线 （共 2 条）
反应条件
1: ortho-difluorobenzene With n-hexyl lithium in tetrahydrofuran; hexane
T=-60°C; 1.25 h;
2: chloroacetyl chloride With copper(l) chloride; zinc(II) chloride in tetrahydrofuran; hexane
T=-60 - 5°C; 0.333333 h;
参考文献
MERCK and CO., INC.
Patent: WO2007/120591 A1, 2007 ;
Location in patent: Page/Page column 8; 24 ;
WO 2007/120591 A1
反应条件
1: ortho-difluorobenzene With n-hexyl lithium in tetrahydrofuran; hexane
T=-60°C; 1 h;
2: With zinc(II) chloride in tetrahydrofuran; hexane
T=-60 - -10°C;
3: chloroacetyl chloride With copper(l) chloride in tetrahydrofuran; hexane
T=-10 - 20°C; Further stages.;
参考文献
Rosen, Jonathan; Steinhuebel, Dietrich; Palucki, Michael; Davies, Ian
Organic Letters, 2007 , vol. 9, # 4 p. 667 - 669
