5-异丙基-1H-吡唑-3-甲酸合成路线 （共 5 条）
反应条件
sodium hydroxide in 1,4-dioxane T=20°C; 18 h;
参考文献
Van Herk; Brussee; Van den Nieuwendijk; Van der Klein; IJzerman; Stannek; Burmeister; Lorenzen
Journal of Medicinal Chemistry, 2003 , vol. 46, # 18 p. 3945 - 3951
反应条件
1: With hydrazine in ethanol 2 h; Heating / reflux; 2: With sodium hydroxide in water T=20°C; 3: With hydrogenchloride in water
参考文献
Ustav Experimentalni Botaniky Akademie ved Ceske Republiky
Patent: EP1475094 A1, 2004 ;
Location in patent: Page 19 ;
反应条件
1: EtONa / ethanol / 18 h / 20 °C 2: N2H4*H2O; AcOH / 8 h / Heating 3: 91 percent / aq. NaOH / dioxane / 18 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 18 p. 3945 - 3951
反应条件
sulfuric acid; nitric acid 1.) room temp., 1 h 2.) 100 deg C, 6 h;
参考文献
Baraldi; Cacciari; Leoni; Recanatini; Roberti; Rossi; Manfredini; Periotto; Simoni
Farmaco, 1991 , vol. 46, # 11 p. 1337 - 1350
反应条件
sulfuric acid 3 h; Heating / reflux;
参考文献
PFIZER LIMITED; PFIZER INC.
Patent: WO2005/9965 A1, 2005 ;
Location in patent: Page/Page column 44-45 ;
WO 2005/009965 A1
