2,3,4,5-四氢-1H-吡啶并[4,3-b]吲哚-8-羧酸合成路线 （共 3 条）
反应条件
sodium hydroxide in methanol; water T=20°C; pH=9 - 10;
参考文献
Ferguson, Fleur M.; Fedorov, Oleg; Chaikuad, Apirat; Philpott, Martin; Muniz, Joao R. C.; Felletar, Ildiko; Von Delft, Frank; Heightman, Tom; Knapp, Stefan; Abell, Chris; Ciulli, Alessio
Journal of Medicinal Chemistry, 2013 , vol. 56, # 24 p. 10183 - 10187
反应条件
hydrogenchloride in 1,4-dioxane
T=17°C; Heating / reflux;
参考文献
ASTRAZENECA AB
Patent: WO2008/36022 A1, 2008 ;
Location in patent: Page/Page column 16 ;
WO 2008/036022 A1
反应条件
hydrogenchloride in 1,4-dioxane; water
Reflux;
参考文献
Cheng, Yun-Xing; Pourashraf, Mehrnaz; Luo, Xuehong; Srivastava, Sanjay; Walpole, Christopher; Salois, Dominic; St-Onge, Stephane; Payza, Kemal; Lessard, Etienne; Yu, Xiao Hong; Tomaszewski, Miroslaw J.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1619 - 1624
