3-正丙基吡唑-5-甲酸乙酯合成路线 （共 9 条）
反应条件
1: C8H16N2O2 With n-butyllithium in tetrahydrofuran; hexane T=-78 - 20°C; 1 h; 2: oxalic acid diethyl ester in tetrahydrofuran; hexane T=-78 - 20°C; 16 h; 3: With toluene-4-sulfonic acid in toluene 10 h; Heating; Further stages.;
参考文献
Dang, Tuan Thanh; Dang, Tung Thanh; Langer, Peter
Tetrahedron Letters, 2007 , vol. 48, # 20 p. 3591 - 3593
反应条件
diethylamine in dimethyl sulfoxide T=20°C; 24 h; regioselective reaction;
参考文献
Wang, Lei; Huang, Jiayao; Gong, Xiaojie; Wang, Jian
Chemistry - A European Journal, 2013 , vol. 19, # 23 p. 7555 - 7560
反应条件
hydrazine monohydrochloride in tetrahydrofuran; ethanol; water T=75°C; 1 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 20 p. 5620 - 5623
反应条件
1: EtONa / ethanol / 18 h / 20 °C 2: N2H4*H2O; AcOH / 8 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 18 p. 3945 - 3951
反应条件
hydrazine hydrate; acetic acid 8 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 18 p. 3945 - 3951
反应条件
sodium hydroxide 5 h; Heating;
参考文献
Seki; Isegawa; Fukuda; Ohki
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 4 p. 1568 - 1577
反应条件
2: NaOH / H2O View Scheme
参考文献
Terrett, Nicholas K.; Bell, Andrew S.; Brown, David; Ellis, Peter
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 15 p. 1819 - 1824
参考文献
Cell Pathways, Inc.
Patent: US6200980 B1, 2001 ;
反应条件
dimethyl sulfate T=90°C; 3 h;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2008/194529 A1, 2008 ;
Location in patent: Page/Page column 56 ;
US 20080194529 A1
