6,7,8,9-四氢-1H-苯并[g]吲哚-2,3-二酮合成路线 （共 5 条）
参考文献
Mayer; Schaefer; Rosenbach
Archiv der Pharmazie (Weinheim, Germany), 1929 , p. 578
Full Text Show Details
v. Braun
Justus Liebigs Annalen der Chemie, 1927 , vol. 451, p. 53
反应条件
1: NH2OH*HCl; Na2SO4; aq. HCl / 55 °C
2: methanesulfonic acid / 1 h / 20 °C
View Scheme
参考文献
Kaila, Neelu; Janz, Kristin; Huang, Adrian; Moretto, Alessandro; DeBernardo, Silvano; Bedard, Patricia W.; Tam, Steve; Clerin, Valerie; Keith Jr., James C.; Tsao, Desiree H.H.; Sushkova, Natalia; Shaw, Gray D.; Camphausen, Raymond T.; Schaub, Robert G.; Wang, Qin
Journal of Medicinal Chemistry, 2007 , vol. 50, # 1 p. 40 - 64
反应条件
nitrobenzene
und anschliessenden Erwaermen mit Aluminiumchlorid;
参考文献
I.G.Farbenind.
Patent: DE514595 , 1928 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 17, p. 646
Full Text Show Details
Gen.Aniline Works
Patent: US1856210 , 1929 ;
反应条件
1: 1H-6,7,8,9-tetrahydro-benz[g]indole-2,3-dione With potassium hydroxide in water
T=90°C; Pfitzinger Reaction; 1 h;
2: 3-lt;4-chlorophenylgt;-2-oxo propanol in tetrahydrofuran; water
T=60°C; 5.5 h;
3: With acetic acid in tetrahydrofuran
T=21 - 50°C;
参考文献
Wang, Youchu
Patent: US2007/82923 A1, 2007 ;
Location in patent: Page/Page column 12 ;
反应条件
potassium hydroxide in ethanol
Pfitzinger reaction; 5 h; Heating;
参考文献
Kaila, Neelu; Janz, Kristin; Huang, Adrian; Moretto, Alessandro; DeBernardo, Silvano; Bedard, Patricia W.; Tam, Steve; Clerin, Valerie; Keith Jr., James C.; Tsao, Desiree H.H.; Sushkova, Natalia; Shaw, Gray D.; Camphausen, Raymond T.; Schaub, Robert G.; Wang, Qin
Journal of Medicinal Chemistry, 2007 , vol. 50, # 1 p. 40 - 64
