9-苯基-1,7-二氮杂双环[4.3.0]壬-2,4,6,8-四烯合成路线 （共 22 条）
反应条件
1: NaNH2; mesitylene
2: aqueous HBr
3: acetic acid anhydride
View Scheme
参考文献
Adams; Dix
Journal of the American Chemical Society, 1958 , vol. 80, p. 4618
反应条件
1: 2-aminopyridine With potassium carbonate in o-di-fluorobenzene
0.75 h;
2: phenyl(phenylethynyl)iodonium trifluoroacetate in o-di-fluorobenzene
T=20°C; DarknessInert atmosphere; SolventReagent/catalystConcentration; Overall yield = 55 percent; regioselective reaction;
参考文献
Dixon, Luke I.; Carroll, Michael A.; Gregson, Thomas J.; Ellames, George J.; Harrington, Ross W.; Clegg, William
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 35 p. 5877 - 5884
反应条件
1: NaNH2; mesitylene
2: aqueous HBr
3: acetic acid anhydride
View Scheme
参考文献
Adams; Dix
Journal of the American Chemical Society, 1958 , vol. 80, p. 4618
参考文献
Adams; Dix
Journal of the American Chemical Society, 1958 , vol. 80, p. 4618
Full Text View citing articles Show Details
Reynaud et al.
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1958 , vol. 247, p. 2159
反应条件
1: aqueous HBr
2: acetic acid anhydride
View Scheme
参考文献
Adams; Dix
Journal of the American Chemical Society, 1958 , vol. 80, p. 4618
Full Text View citing articles Show Details
Reynaud et al.
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1958 , vol. 247, p. 2159
反应条件
1: 2-aminopyridine With potassium carbonate in o-di-fluorobenzene
0.75 h;
2: Ph-EBX in o-di-fluorobenzene
T=20°C; DarknessInert atmosphereReflux; Overall yield = 54 percent; regioselective reaction;
参考文献
Dixon, Luke I.; Carroll, Michael A.; Gregson, Thomas J.; Ellames, George J.; Harrington, Ross W.; Clegg, William
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 35 p. 5877 - 5884
反应条件
1: 2-aminopyridine With potassium carbonate in o-di-fluorobenzene
0.75 h;
2: PhI(+)CCPhTsO(-) in o-di-fluorobenzene
T=20°C; DarknessInert atmosphere; Overall yield = 62 percent; regioselective reaction;
参考文献
Dixon, Luke I.; Carroll, Michael A.; Gregson, Thomas J.; Ellames, George J.; Harrington, Ross W.; Clegg, William
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 35 p. 5877 - 5884
反应条件
1: 87 percent / N-iodosuccinimide / acetonitrile / 0.5 h / 20 °C
2: 69 percent / Pd(PPh3)4; aq. NaOH / 1,2-dimethoxy-ethane / 0.5 h / 75 °C
View Scheme
参考文献
Enguehard, Cecile; Renou, Jean-Louis; Collot, Valerie; Hervet, Maud; Rault, Sylvain; Gueiffier, Alain
Journal of Organic Chemistry, 2000 , vol. 65, # 20 p. 6572 - 6575
反应条件
1.1: trimethylsilyl trifluoromethanesulfonate / acetonitrile / 0.92 h / |Inert atmosphere
1.2: 1 h
1.3: 0.75 h
2.1: potassium carbonate / o-di-fluorobenzene / 0.75 h
2.2: 20 °C / |Darkness; |Inert atmosphere; |Reflux
View Scheme
参考文献
Dixon, Luke I.; Carroll, Michael A.; Gregson, Thomas J.; Ellames, George J.; Harrington, Ross W.; Clegg, William
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 35 p. 5877 - 5884
反应条件
1: aqueous NaHCO3
2: 210 - 220 °C
View Scheme
参考文献
Gol'dfarb; Kondakowa
Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation), 1942 , vol. 15, p. 151,158
Chem.Abstr., 1943 , p. 2380
