5-溴-3-甲基-1H-吡唑并[3,4-c]吡啶合成路线 （共 4 条）
反应条件
hydrazine in ethylene glycol T=165°C; 3.5 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2009/32651 A1, 2009 ;
Location in patent: Page/Page column 8; 32 ;
WO 2009/032651 A1
反应条件
acetic acid; sodium nitrite in water T=20°C; 24 h;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 15, # 6 p. 2441 - 2452
反应条件
1: 90 percent / hydrogen / nickel / tetrahydrofuran / 18 h 2: acetic acid; sodium nitrite / H2O / 24 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 15, # 6 p. 2441 - 2452
反应条件
1: 54 percent / hydrobromic acid; Br2 / 1.5 h / cooling 2: 90 percent / hydrogen / nickel / tetrahydrofuran / 18 h 3: acetic acid; sodium nitrite / H2O / 24 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 15, # 6 p. 2441 - 2452
