5-溴-1H-吡唑并[3,4-c]吡啶-1-羧酸叔丁酯合成路线 （共 3 条）
反应条件
1: hydrogen / nickel / tetrahydrofuran
2: 3.9 g / acetic acid; sodium nitrite / H2O / 72 h / 20 °C
3: triethylamine; 4-(dimethylamino)pyridine / acetonitrile / 20 °C
View Scheme
参考文献
Zhu, Gui-Dong; Gong, Jianchun; Gandhi, Viraj B.; Woods, Keith; Luo, Yan; Liu, Xuesong; Guan, Ran; Klinghofer, Vered; Johnson, Eric F.; Stoll, Vincent S.; Mamo, Mulugeta; Li, Qun; Rosenberg, Saul H.; Giranda, Vincent L.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 6 p. 2441 - 2452
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in acetonitrile
T=20°C;
参考文献
Zhu, Gui-Dong; Gong, Jianchun; Gandhi, Viraj B.; Woods, Keith; Luo, Yan; Liu, Xuesong; Guan, Ran; Klinghofer, Vered; Johnson, Eric F.; Stoll, Vincent S.; Mamo, Mulugeta; Li, Qun; Rosenberg, Saul H.; Giranda, Vincent L.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 6 p. 2441 - 2452
反应条件
1: 3.9 g / acetic acid; sodium nitrite / H2O / 72 h / 20 °C
2: triethylamine; 4-(dimethylamino)pyridine / acetonitrile / 20 °C
View Scheme
参考文献
Zhu, Gui-Dong; Gong, Jianchun; Gandhi, Viraj B.; Woods, Keith; Luo, Yan; Liu, Xuesong; Guan, Ran; Klinghofer, Vered; Johnson, Eric F.; Stoll, Vincent S.; Mamo, Mulugeta; Li, Qun; Rosenberg, Saul H.; Giranda, Vincent L.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 6 p. 2441 - 2452
