2-氨基-1-吡啶-3-乙醇合成路线 (共 10 条)
反应条件
hydrogenchloride; platinum Hydrogenation;
参考文献
Burrus; Powell
Journal of the American Chemical Society, 1945 , vol. 67, p. 1468,1469
Full Text Show Details
Zymalkowski; Koppe
Archiv der Pharmazie (Weinheim, Germany), 1961 , vol. 294, p. 453,456
反应条件
sodium tetrahydroborate in water; isopropyl alcohol
T=20°C; 12 h;
参考文献
OSI PHARMACEUTICALS, INC.
Patent: WO2004/104001 A2, 2004 ;
Location in patent: Page 67 ;
WO 2004/104001 A2
反应条件
10 Pd/C; hydrogen in methanol
T=20°C; 12 h;
参考文献
Bhabak, Krishna P.; Arenz, Christoph
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 20 p. 6162 - 6170
反应条件
hydrogenchloride; palladium
Hydrogenation;
参考文献
Zymalkowski
Archiv der Pharmazie (Weinheim, Germany), 1958 , vol. 291, p. 12,18, 20
Full Text Show Details
Burrus; Powell
Journal of the American Chemical Society, 1945 , vol. 67, p. 1468,1469
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran; N,N-dimethyl-formamide
48 h; Ambient temperature;
参考文献
Tsuge, Otohiko; Kanemasa, Shuji; Hatada, Akira; Matsuda, Koyo
Bulletin of the Chemical Society of Japan, 1986 , vol. 59, p. 2537 - 2546
反应条件
1: sodium ethylate; ethanol
2: palladium; methanol. HCl / Hydrogenation
View Scheme
参考文献
Burrus; Powell
Journal of the American Chemical Society, 1945 , vol. 67, p. 1468,1469
反应条件
hydrogenchloride; palladium
Hydrogenation;
参考文献
Burrus; Powell
Journal of the American Chemical Society, 1945 , vol. 67, p. 1468,1469
反应条件
1: aqueous NaOH; NaNO2
2: ethanol; SnCl2+2 H2O; concentrated aqueous HCl
3: palladium; aqueous HCl / Hydrogenation
View Scheme
参考文献
Burrus; Powell
Journal of the American Chemical Society, 1945 , vol. 67, p. 1468,1469
反应条件
1: ethanol; SnCl2+2 H2O; concentrated aqueous HCl
2: palladium; aqueous HCl / Hydrogenation
View Scheme
参考文献
Burrus; Powell
Journal of the American Chemical Society, 1945 , vol. 67, p. 1468,1469
反应条件
1: triethylamine / 20 °C / |Inert atmosphere
2: 10 Pd/C; hydrogen / methanol / 12 h / 20 °C
View Scheme
参考文献
Bhabak, Krishna P.; Arenz, Christoph
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 20 p. 6162 - 6170