1: With n-butyllithium; LiDMAE in hexane T=0°C; 1 h; 2: With carbon tetrabromide in hexane T=-78°C; 1 h;

phosphorus tribromide 3 h; Heating;

1: With n-butyllithium; diisopropylamine in diethyl ether T=-78°C; 0.416667 h; 2: With bromine in diethyl ether T=-78 - 20°C; 3: With water in diethyl ether regioselective reaction;

sulfuric acid; bromine T=155 - 175°C; 24 h;

1: With N-(diphenylmethylene)amine; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0) in toluene T=80°C; 1.5 h; Inert atmosphere; 2: With hydrogenchloride in tetrahydrofuran; water T=20°C; 3 h;

1.1: K3PO4*3H2O / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / Inert atmosphere; Reflux 2.1: cesium fluoride / dimethyl sulfoxide / 18 h / 120 °C 3.1: trifluoroacetic acid / dichloromethane / 18 h 3.2: pH 11 4.1: benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane / 0.5 h / 20 °C 4.2: 18 h / 20 °C View Scheme