2,5-二甲氧基苯甲醛合成路线 （共 179 条）
参考文献
Kauffmann
Chemische Berichte, 1917 , vol. 50, p. 635
Chemische Berichte, 1919 , vol. 52, p. 1431
反应条件
potassium tert-butylate in dichloromethane; tert-butyl alcohol 4 h;
参考文献
Gonzalez, Juan Francisco; De La Cuesta, Elena; Avendano, Carmen
Tetrahedron Letters, 2003 , vol. 44, # 23 p. 4395 - 4398
反应条件
1: tetrahydrofuran / 1 h / Heating 2: PDC / CH2Cl2 / 48 h / Ambient temperature 3: 20 percent / piperidine, glacial acetic acid / ethanol / 48 h / Heating View Scheme
参考文献
Ducki, Sylvie; Forrest, Richard; Hadfield, John A.; Kendall, Alex; Lawrence, Nicholas J.; McGown, Alan T.; Rennison, David
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 9 p. 1051 - 1056
反应条件
hydrogenchloride; nitric acid 1.) acetic anhydride, from 10 deg C to 15 deg C, 1 h, 2.) acetic anhydride, 2 h; Yield given. Multistep reaction;
参考文献
Cotelle; Catteau
Synthetic Communications, 1992 , vol. 22, # 14 p. 2071 - 2076
反应条件
nitric acid; acetic acid in diethyl ether 30 h; Ambient temperature;
参考文献
Del Mar Blanco; Avendano; Cabezas; Menendez
Synthetic Communications, 1993 , vol. 23, # 10 p. 1351 - 1356
反应条件
1: 96 percent / CuSO4 2: 30 percent / 70percent HNO3 / acetic anhydride / 1 h / 10 - 15 °C View Scheme
参考文献
Cotelle; Catteau
Synthetic Communications, 1992 , vol. 22, # 14 p. 2071 - 2076
反应条件
sodium hydroxide in ethanol; water
T=20°C; Claisen-Schmidt Condensation;
参考文献
Hwang, Ki-Jun; Kim, Ho-Seok; Han, In-Cheol; Kim, Beom-Tae
Bulletin of the Korean Chemical Society, 2012 , vol. 33, # 8 p. 2585 - 2591
反应条件
1: 76 percent / t-BuOK / tetrahydrofuran / 0.75 h / -20 °C
2: 3 percent / NaBH4 / dimethylformamide / 0.5 h / 60 °C
3: 84 percent / BBr3 / CH2Cl2 / 1.) -78 deg C, 60 min, 2.) room temp., 90 min
View Scheme
参考文献
Anderson, Wayne K.; Dabrah, Thomas T.; Houston, D. Michael
Journal of Organic Chemistry, 1987 , vol. 52, # 13 p. 2945 - 2947
反应条件
1: tin(IV) chloride; bromine / dichloromethane / 20 °C / |Inert atmosphere; |Reflux
2: borane dimethyl sulfide complex / chlorobenzene / 21 h / 0 - 130 °C / |Inert atmosphere
3: sodium t-butanolate; palladium diacetate; [(t-Bu)3PH]BF4 / toluene / 3 h / 160 °C / |Inert atmosphere; |Microwave irradiation
4: boron tribromide / dichloromethane / 18 h / -78 - 20 °C / |Inert atmosphere
View Scheme
参考文献
Bedford, Robin B.; Bowen, John G.; Weeks, Amanda L.
Tetrahedron, 2013 , vol. 69, # 22 p. 4389 - 4394
反应条件
hydrogen iodide in butan-1-ol
1.5 h; Heating;
参考文献
Yutilov, Yu. M.; Ignatenko, A. G.; Afanas'ev, B. E.; Kirichenko, V. V.; Orestenko, L. P.; Linenko, V. I.
Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 6 p. 490 - 493
Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 6 p. 697 - 699
