2,5-二甲氧基苯甲醛合成路线 （共 179 条）
反应条件
1: 1.3 g / various solvent(s) / 20 h / 160 °C
2: 250 mg / Cu-bronz / quinoline / 7 h / 240 - 260 °C
3: Pd-C / methanol / 3 h / Ambient temperature
View Scheme
参考文献
Juneja, R. K.; Sharma, S. C.; Tandon, J. S.
Phytochemistry (Elsevier), 1985 , vol. 24, # 2 p. 321 - 324
反应条件
1: samarium diiodide / tetrahydrofuran; hexamethylphosphoric acid triamide / 3 h / 0 - 20 °C
2: 80 percent / PDC / CH2Cl2 / 3 h
View Scheme
参考文献
Shiue, Jiann-Shyng; Lin, Mei-Huey; Fang, Jim-Min
Journal of Organic Chemistry, 1997 , vol. 62, # 14 p. 4643 - 4649
反应条件
1: piperidine / Hydrierung des Reaktionsprodukts, Behandlung des erhaltenen Esters mit Methyljodid und Natriumaethylat und anschliessend Hydrolyse
2: 150 °C
3: ammonia / 220 - 230 °C
4: dioxane; aqueous sodium hypochlorite
View Scheme
参考文献
Coutts; Malicky
Canadian Journal of Chemistry, 1973 , vol. 51, # 9 p. 1402 - 1409
反应条件
(i) NH4OAc, (ii) LiAlH4, THF; Multistep reaction;
参考文献
Ho,B.T. et al.
Journal of Medicinal Chemistry, 1970 , vol. 13, p. 26 - 30
反应条件
1.1: NaH / tetrahydrofuran / 0.5 h / 20 °C
1.2: 100 percent / tetrahydrofuran / 6 h / 20 °C
2.1: 100 percent / H2 / Pd/C / methanol / 4 h / 20 °C / 760 Torr
View Scheme
参考文献
Srikrishna; Satyanarayana; Desai, Uday V.
Synthetic Communications, 2007 , vol. 37, # 6 p. 965 - 976
反应条件
piperidine
katalytische Hydrierung des Reaktionsprodukts und anschliessende Hydrolyse;
参考文献
Baltzly; Buck
Journal of the American Chemical Society, 1940 , vol. 62, p. 164,166
Journal of the American Chemical Society, 1942 , vol. 64, p. 3040
反应条件
toluene-4-sulfonic acid in benzene
Heating;
参考文献
Sato, Kenichiro; Asao, Naoki; Yamamoto, Yoshinori
Journal of Organic Chemistry, 2005 , vol. 70, # 22 p. 8977 - 8981
参考文献
Dimmock; Nyathi; Smith
Journal of Pharmaceutical Sciences, 1979 , vol. 68, # 10 p. 1216 - 1221
反应条件
1: 64 percent / piperidine / benzene; acetic acid / 3 h / Heating
2: 89 percent / H2 / 5percent Pd/C / ethyl acetate / 2 h / 1034.3 - 2068.6 Torr
3: 62 percent / diphenyl ether / 1.5 h / 195 - 230 °C
4: 40 percent / SOCl2*DMF / CHCl3 / 3 h / Heating
5: 38 percent / KOH, H2 / 5percent Pd/C / ethanol / 36 h / 1810.02 - 2068.6 Torr
View Scheme
参考文献
Grivsky, Eugene M.; Lee, Shuliang; Sigel, Carl W.; Duch, David S.; Nichol, Charles A.
Journal of Medicinal Chemistry, 1980 , vol. 23, # 3 p. 327 - 329
反应条件
1.1: AlCl3, aluminium chloride / dichloromethane / 4 h / 0 - 20 °C
1.2: 0 °C
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C
2.2: 0 - 20 °C
View Scheme
参考文献
Radomkit, Suttipol; Sarnpitak, Pakornwit; Tummatorn, Jumreang; Batsomboon, Paratchata; Ruchirawat, Somsak; Ploypradith, Poonsakdi
Tetrahedron, 2011 , vol. 67, # 21 p. 3904 - 3914
