2,5-二甲氧基苯甲醛合成路线 （共 179 条）
反应条件
1: 1.) Mg / 2.) anh. Et2O
2: 3.0 g / 98percent H2SO4 / acetic acid / Ambient temperature
View Scheme
参考文献
Natoli, Maria C.; Agozzino, Pasquale; Ceraulo, Leopoldo; Lamartina, Liliana
Gazzetta Chimica Italiana, 1983 , vol. 113, # 7/8 p. 493 - 502
反应条件
iodine; silver nitrate in methanol
7 h;
参考文献
Hathaway, Bruce A.; Taylor, Brian E.; Wittenborn, Jeremy S.
Synthetic Communications, 1998 , vol. 28, # 24 p. 4629 - 4637
反应条件
1.1: sodium acetate; acetic anhydride; acetic acid / 3 h / 170 °C / Inert atmosphere
2.1: palladium 10 on activated carbon; hydrogen / ethanol / 5 h / 20 °C / 2585.81 Torr
3.1: Ba(OH)2·8H2O / water / 48 h / Reflux
3.2: pH 6.5
3.3: pH 9
View Scheme
参考文献
Al-Horani, Rami A.; Desai, Umesh R.
Tetrahedron, 2012 , vol. 68, # 8 p. 2027 - 2040
反应条件
1: 1) MeLi / 1) THF, -70 deg C, 1 h, 2) THF, -70 deg C to RT, overnight
2: 85 percent / 6N HCl / Heating
View Scheme
参考文献
Croisy-Delcey; Carrez; Bisagni
European Journal of Medicinal Chemistry, 1988 , vol. 23, # 1 p. 101 - 106
反应条件
1: toluene / 4 h / |Reflux; |Dean-Stark
2: sodium tetrahydroborate / methanol / 3 h / 20 °C
3: sodium carbonate / dichloromethane / 6 h / 20 °C
4: hydrogenchloride / 1,4-dioxane / 7 h / |Inert atmosphere; |Reflux
5: N-bromosuccinmide; sulfuric acid / water; tetrahydrofuran / 48 h / 20 °C
View Scheme
参考文献
Naciuk, Fabricio F.; Milan, Julio C.; Andreao, Almir; Miranda, Paulo C.M.L.
Journal of Organic Chemistry, 2013 , vol. 78, # 10 p. 5026 - 5030
反应条件
1: 85 percent / potassium permanganate / H2O / 1 h / 80 °C
2: 72 percent / cc. nitric acid / 3 h / 0 - 2 °C
View Scheme
参考文献
Azadi-Ardakani, Manouchehr; Wallace, Timothy W.
Tetrahedron, 1988 , vol. 44, # 18 p. 5939 - 5952
反应条件
1: 85 percent / potassium permanganate / H2O / 1 h / 80 °C
2: 72 percent / cc. nitric acid / 3 h / 0 - 2 °C
3: 93 percent / H2 / 10 percent Pd-C / ethanol / 6 h / 38000 Torr
View Scheme
参考文献
Azadi-Ardakani, Manouchehr; Wallace, Timothy W.
Tetrahedron, 1988 , vol. 44, # 18 p. 5939 - 5952
反应条件
1: 93 percent / piperidine, HOAc / benzene / 14 h / Heating
2: 1) H2; 2) NaH / 1) 10percent Pt-C / 1) THF, 5 h, 59 -> 27 lb/square inch; 2) THF, reflux, 5 h
View Scheme
参考文献
Swenton; Freskos; Morrow; Sercel
Tetrahedron, 1984 , vol. 40, # 22 p. 4625 - 4632
反应条件
hydrogen sulfide in ethanol
参考文献
Boehringer Ingelheim GmbH
Patent: US3985891 A1, 1976 ;
US 3985891 A
反应条件
1: piperidine / Hydrierung des Reaktionsprodukts, Behandlung des erhaltenen Esters mit Methyljodid und Natriumaethylat und anschliessend Hydrolyse
2: 150 °C
3: ammonia / 220 - 230 °C
4: dioxane; aqueous sodium hypochlorite
5: und Erwaermen des Reaktionsprodukts mit Methyljodid und anschliessend mit Aethanol
View Scheme
参考文献
Baltzly; Buck
Journal of the American Chemical Society, 1940 , vol. 62, p. 164,166
Journal of the American Chemical Society, 1942 , vol. 64, p. 3040
