2,5-二甲氧基苯甲醛合成路线 （共 179 条）
反应条件
1: zinc iodide / 1 h / Ambient temperature 2: 1.) lithium aluminum hydride, 2.) HCl / 1.) THF, reflux, 2 h, 2.) methanol, ether View Scheme
参考文献
Philippo; Fett; Bovy; Barras; Angel; Georges; Ochsenbein
European Journal of Medicinal Chemistry, 1997 , vol. 32, # 11 p. 881 - 888
反应条件
1: 100 percent / toluene / 4 h / Heating 2: 99.9 percent / sodium borohydride / ethanol / 20 h / Ambient temperature 3: 95 percent / 6 N HCl / 30 h / 40 - 42 °C View Scheme
参考文献
Mitscher; Gill; Filppi; Wolgemuth
Journal of Medicinal Chemistry, 1986 , vol. 29, # 7 p. 1277 - 1281
反应条件
1: 82 percent / NaH / dimethylsulfoxide; tetrahydrofuran / 1. 0 deg C, 2. room temp., 15 h. 2: 91 percent / H2 / 10percent Pd/C / ethanol / 0.33 h 3: 72 percent / polyphosphoric acid / 0.5 h / 85 °C View Scheme
参考文献
Salley, John J.; Glennon, Richard A.
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 545 - 550
反应条件
piperidine; pyridine T=50 - 85°C; Knoevenagel Condensation; 5 h; Reflux;
参考文献
Chaaban, Ibrahim; El Khawass, El Sayeda M.; Mahran, Mona A.; Abd El Razik, Heba A.; El Salamouni, Nehad S.; Abdel Wahab, Abeer E.
Medicinal Chemistry Research, 2013 , vol. 22, # 8 p. 3760 - 3778
反应条件
sodium acetate T=180°C;
参考文献
Kauffmann; Burr
Chemische Berichte, 1907 , vol. 40, p. 2357
反应条件
nitric acid; silica gel
参考文献
Synlett, , # 9 p. 1431 - 1434
反应条件
hydrogenchloride; nitric acid 1.) acetic anhydride, from 10 deg C to 15 deg C, 1 h, 2.) acetic anhydride, 2 h; Yield given. Multistep reaction;
参考文献
Synthetic Communications, , vol. 22, # 14 p. 2071 - 2076
反应条件
nitric acid Ambient temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 8 p. 1329 - 1340
反应条件
nitric acid; acetic acid in diethyl ether 30 h; Ambient temperature;
参考文献
Synthetic Communications, , vol. 23, # 10 p. 1351 - 1356
参考文献
Medicinal Chemistry Research, , vol. 9, # 6 p. 374 - 388
