1.1: bromine / acetic acid / 20 °C 2.1: magnesium / tetrahydrofuran / 2 h / |Inert atmosphere 2.2: -78 - 20 °C / |Inert atmosphere 3.1: tetrakis(triphenylphosphine) palladium(0) / ethylene glycol dimethyl ether / 0.5 h 3.2: |Reflux 4.1: boron tribromide / dichloromethane / 20 °C / |Reflux 5.1: 4-(N,N-dimethlyamino)pyridine / dichloromethane / 20 °C 6.1: Cl2Ni(1,2-bis(diphenylphosphino)ethane) / N,N-dimethyl-formamide / 0.5 h / 20 °C / |Heating 6.2: 40 h / 100 °C View Scheme
参考文献
Lim, Chung Woo; Tissot, Olivier; Mattison, Andrew; Hooper, Mark W.; Brown, John M.; Cowley, Andrew R.; Hulmes, David I.; Blacker, A. John
Organic Process Research and Development, 2003 , vol. 7, # 3 p. 379 - 384
1: 88 percent / AlCl3 / CH2Cl2 / 12 h / 25 °C 2: 90 percent / diethyl ether / 1.) 20 deg C, 10 h, 2.) reflux, 30 min 3: 90 percent / POCl3, Py / CH2Cl2 / 0 - 25 °C 4: K3Fe(CN)6, K2CO3, OsO4, (DHQD)2-PHAL, MeSO2NH2 / H2O; 2-methyl-propan-2-ol; toluene / 28 h / 0 °C 5: HCOONH4 / Pd-C / ethanol / 6 h / Heating 6: Jone's reagent / acetone / 8 h / 0 °C View Scheme
参考文献
Nandanan; Jayachandran; Phukan, Prodeep; Pais, Godwin C. G.; Sudalai
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1998 , vol. 37, # 12 p. 1221 - 1227
