3,4-二甲氧基苯甲酸合成路线 （共 364 条）
反应条件
hydrogenchloride; bromine in water T=20 - 30°C; 3 h; Concentration;
参考文献
Zeria Pharmaceutical Co., LTD; Nakao, Ryu
Patent: US2013/253222 A1, 2013 ;
Location in patent: Paragraph 0028; 0029; 0033 ;
反应条件
1: barytes / beim Gluehen 2: bromine View Scheme
参考文献
Merck
Justus Liebigs Annalen der Chemie, 1858 , vol. 108, p. 60
反应条件
1.1: 99 percent / thionyl chloride; urea / toluene / 3 h / 100 °C 2.1: magnesium; ethanol / toluene; CCl4 / 1 h / Heating 2.2: 95 percent / toluene; CCl4 / 0.5 h / 20 °C 3.1: 90 percent / p-TsOH*H2O / H2O / 7 h / Heating View Scheme
参考文献
Zotova, S. A.; Gololobova, T. M.; Stolyarchuk, A. A.; Stepanyuk, G. I.; Bobruk, V. P.; et al.
Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 1 p. 26 - 30
Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 1 p. 35 - 39
反应条件
1: 3,4-dimethoxy-benzoic acid With 1,1'-carbonyldiimidazole in tetrahydrofuran 0.5 h; Heating; 2: malonic acid ethyl ester monopotassium salt With magnesium chloride in tetrahydrofuran T=20°C; Further stages.;
参考文献
Jae; Winn; Von Geldern; Sorensen; Chiou; Nguyen; Marsh; Opgenorth
Journal of Medicinal Chemistry, 2001 , vol. 44, # 23 p. 3978 - 3984
反应条件
barytes beim Gluehen;
参考文献
Merck
Justus Liebigs Annalen der Chemie, 1858 , vol. 108, p. 60
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Koelle
Justus Liebigs Annalen der Chemie, 1871 , vol. 159, p. 243
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Koerner
Gazzetta Chimica Italiana, 1876 , vol. 6, p. 144
Jahresbericht ueber die Fortschritte der Chemie und Verwandter Theile Anderer Wissenschaften, 1876 , p. 601
反应条件
1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 1.5 h / 0 °C / Inert atmosphere 2: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere 3: lithium hexamethyldisilazane / tetrahydrofuran / -30 - 0 °C / Inert atmosphere 4: trifluoroacetic acid / methanol / 24 h / 50 °C View Scheme
参考文献
Chemical Communications, , vol. 47, # 10 p. 2868 - 2870
反应条件
1: (COCl)2 / CH2Cl2 / 1 h / 0 - 20 °C 2: AlCl3 / 0 - 20 °C View Scheme
参考文献
Negash; Nichols; Watts; Mailman
Journal of medicinal chemistry, 1997 , vol. 40, # 14 p. 2140 - 2147
反应条件
hydrazine hydrate 0.0416667 h; Microwave irradiation;
参考文献
Saha, Ajoy; Kumar, Rajesh; Kumar, Rajendra; Devakumar
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2010 , vol. 49, # 4 p. 526 - 531
反应条件
1: SOCl2 / CHCl3 / Heating 2: toluene / Ambient temperature 3: 1.) t-BuLi / 1.) THF, -78 deg C, 15 min, 2.) THF, from -78 to -65 deg C, 4 h View Scheme
参考文献
Pettit, George R.; Toki, Brian; Herald, Delbert L.; Verdier-Pinard, Pascal; Boyd, Michael R.; Hamel, Ernest; Pettit, Robin K.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 10 p. 1688 - 1695
反应条件
1: 89 percent / HCl; NH4OH / 20 h / 15 - 30 °C 2: 85 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating View Scheme
参考文献
Ameur Meziane, Mohamed Ait; Royer, Sylvain; Bazureau, Jean Pierre
Tetrahedron Letters, 2001 , vol. 42, # 6 p. 1017 - 1020
