3,4-二甲氧基苯甲酸合成路线 （共 364 条）
反应条件
1: SOCl2 / CHCl3 / Heating 2: toluene / Ambient temperature View Scheme
参考文献
Pettit, George R.; Toki, Brian; Herald, Delbert L.; Verdier-Pinard, Pascal; Boyd, Michael R.; Hamel, Ernest; Pettit, Robin K.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 10 p. 1688 - 1695
反应条件
1: SOCl2, DMF 2: Et3N / CH2Cl2 / 2 h / Ambient temperature 3: 1.) BBr3, 2.) H2O / 1.) r.t., 48 h, 2.) 100 deg C, 4 h View Scheme
参考文献
Caulder; Raymond
Angewandte Chemie - International Edition in English, 1997 , vol. 36, # 13-14 p. 1440 - 1442
反应条件
1: 3,4-dimethoxy-benzoic acid With cytochrome P450 enzyme CYP199A4 from Rhodopseudomonas palustris HaA2; nicotinamide adenine dinucleotide; bovine liver catalase in ethanol pH=7.4; Enzymatic reaction; 2: N,O-bis(trimethylsilyl) trifluoroacetamide With chloro-trimethyl-silane in acetonitrile 2 h;
参考文献
Bell, Stephen G.; Zhou, Ruimin; Yang, Wen; Tan, Adrian B. H.; Gentleman, Alexander S.; Wong, Luet-Lok; Zhou, Weihong
Chemistry - A European Journal, 2012 , vol. 18, # 52 p. 16677 - 16688
参考文献
Napoly, Francois; Jean-Gerard, Ludivine; Goux-Henry, Catherine; Draye, Micheline; Andrioletti, Bruno
European Journal of Organic Chemistry, 2014 , vol. 2014, # 4 p. 781 - 787
参考文献
Shi, Zhen; Gu, Huan
Synthetic Communications, 1997 , vol. 27, # 15 p. 2701 - 2707
反应条件
1: SOCl2 / 2 h / Ambient temperature 2: diethyl ether / 0.5 h / 0 °C 3: concd aq. HCl / diethyl ether / 3 h / -20 °C View Scheme
参考文献
Hagishita, Sanji; Seno, Kaoru; Kamata, Susumu; Haga, Nobuhiro; Ishihara, Yasunobu; Ishikawa, Michio; Shimamura, Mayumi
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 7 p. 1433 - 1446
反应条件
boric acid in xylene 12 h; Heating;
参考文献
Dobbs, Adrian P.; Jones, Keith; Veal, Ken T.
Tetrahedron Letters, 1997 , vol. 38, # 30 p. 5379 - 5382
反应条件
1: 47.8 percent / toluene / 110 °C 2: 1.) Na, 2.) aq. oxalic acid / 1.) C2H5OH, 0 deg C to 5 deg C, 40 min, 2.) reflux View Scheme
参考文献
Shi, Zhen; Gu, Huan
Synthetic Communications, 1997 , vol. 27, # 15 p. 2701 - 2707
反应条件
hydrogen iodide 4 h; Heatinglabelled comp.; Yield given;
参考文献
Koerner
Gazzetta Chimica Italiana, 1876 , vol. 6, p. 144
Jahresbericht ueber die Fortschritte der Chemie und Verwandter Theile Anderer Wissenschaften, 1876 , p. 601
参考文献
Koerner
Gazzetta Chimica Italiana, 1876 , vol. 6, p. 144
Jahresbericht ueber die Fortschritte der Chemie und Verwandter Theile Anderer Wissenschaften, 1876 , p. 601
