3,4-二甲氧基苯甲酸合成路线 （共 364 条）
反应条件
1: sec.-butyllithium; 3,4-dimethoxy-benzoic acid With N,N,N',N,-tetramethylethylenediamine in tetrahydrofuran; hexane; cyclohexane T=-78 - -30°C; 2 h; 2: methyl iodide in tetrahydrofuran; hexane; cyclohexane T=-30 - 20°C; Further stages.;
参考文献
Tetrahedron, , vol. 64, # 46 p. 10552 - 10557
反应条件
1: aqueous hydrobromic acid 2: hydrogen chloride View Scheme
参考文献
Lovecy; Robinson; Sugasawa
Journal of the Chemical Society, 1930 , p. 817,818
反应条件
1: With n-butyllithium; 2,2,6,6-tetramethylpiperidinyl-lithium in tetrahydrofuran; hexane T=-78 - 0°C; 2: With 1,2,2-trichloro-1,1,2-trichloro-ethane in tetrahydrofuran; hexane 1 h; Heating; Further stages.;
参考文献
Chau, Nguyet Trang Thanh; Nguyen, Thi Huu; Castanet, Anne-Sophie; Nguyen, Kim Phi Phung; Mortier, Jacques
Tetrahedron, 2008 , vol. 64, # 46 p. 10552 - 10557
反应条件
1: aqueous hydrobromic acid 2: hydrogen chloride 3: methanol. KOH-solution 4: aqueous KOH-solution 5: diethyl ether; thionyl chloride; pyridine 6: sodium-<3-benzyloxy-4-methoxy benzoate> / 190 °C / Erwaermen des Reaktionsprodukts mit wss.-aethanol. Kalilauge 7: acetic acid; aqueous hydrochloric acid View Scheme
参考文献
Lovecy; Robinson; Sugasawa
Journal of the Chemical Society, 1930 , p. 817,818
参考文献
Stenlake; Waigh; Urwin; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 6 p. 503 - 507
反应条件
1: 80 percent / DCC, DMAP / acetonitrile / Ambient temperature 2: 60 percent / CH2Cl2 / 1 h / Ambient temperature View Scheme
参考文献
Landais; Rambault; Robin
Tetrahedron Letters, 1987 , vol. 28, # 5 p. 543 - 546
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine in N,N-dimethyl-formamide T=20°C; 3 h;
参考文献
Hayashi, Yoshio; Yamazaki, Yuri; Sumikura, Makiko; Masuda, Yurika; Hayashi, Yoshiki; Yasui, Hiroyuki; Kiso, Yoshiaki; Chinen, Takumi; Usui, Takeo; Yakushiji, Fumika; Potts, Barbara; Neuteboom, Saskia; Palladino, Michael; Lloyd, George Kenneth
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 14 p. 4279 - 4289
反应条件
triethylamine; 1,1'-carbonyldiimidazole
参考文献
Lee, Ki-Ho; Park, Chun-Eung; Min, Kyung-Hyun; Shin, Yong-Je; Chung, Coo-Min; Kim, Hui-Ho; Yoon, Hae-Jeoung; Won-Kim; Ryu, Eun-Ju; Shin, Yu-Jin; Nam, Hyun-Sik; Cho, Jeong-Woo; Lee, Hee-Yoon
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 18 p. 5567 - 5571
反应条件
1: diluted hydrochloric acid / 160 - 170 °C / im geschlossenen Rohr View Scheme
参考文献
Chemische Berichte, , vol. 11, p. 133
反应条件
trimethylamine borane in xylene 9 h; Heating;
参考文献
Synthesis, , # 9 p. 853 - 854
