3,4-二甲氧基苯甲酸合成路线 （共 364 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C; Reduction; r.t., overnight;
参考文献
Nishiwaki, Hisashi; Nakagawa, Yoshiaki; Takeda, David Y.; Okazawa, Atsushi; Akamatsu, Miki; Miyagawa, Hisashi; Ueno, Tamio; Nishimura, Keiichiro
Pest Management Science, 2000 , vol. 56, # 10 p. 875 - 881
反应条件
potassium hydroxide; samarium diiodide in tetrahydrofuran; water 0.00194444 h; Ambient temperature;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 65, # 11 p. 3049 - 3054
反应条件
nitric acid 1 h; Cooling; Product distribution / selectivity;
参考文献
IND-SWIFT LABORATORIES LIMITED; AGGARWAL, Ashvin, Kumar; JAIN, Anshul, Kumar; CHIDAMBARAM, Venkateswaran, Srinivasan; WADHWA, Lalit
Patent: WO2010/76810 A2, 2010 ;
Location in patent: Page/Page column 15 ;
参考文献
Merck
Justus Liebigs Annalen der Chemie, 1858 , vol. 108, p. 60
Full Text Show Details
Tiemann; Matsmoto
Chemische Berichte, 1876 , vol. 9, p. 939
Chemische Berichte, 1878 , vol. 11, p. 131
Full Text Show Details
Zincke; Francke
Justus Liebigs Annalen der Chemie, 1896 , vol. 293, p. 190
参考文献
Merck
Justus Liebigs Annalen der Chemie, 1858 , vol. 108, p. 60
Full Text Show Details
Tiemann; Matsmoto
Chemische Berichte, 1876 , vol. 9, p. 939
Chemische Berichte, 1878 , vol. 11, p. 131
Full Text Show Details
Zincke; Francke
Justus Liebigs Annalen der Chemie, 1896 , vol. 293, p. 190
反应条件
1: sulfuric acid / Reflux 2: nitric acid; acetic acid / 0 - 5 °C 3: 10 palladium on activated charcoal; hydrogen 4: 160 - 170 °C View Scheme
参考文献
Chen, Yurong; Feng, Man; Li, Shilei; Xu, Jingli; Ning, Hongyu; He, Yong; Wang, Xiao; Ding, Rui; Qi, Chuanmin
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 14 p. 4745 - 4749
参考文献
Merck
Justus Liebigs Annalen der Chemie, 1858 , vol. 108, p. 60
反应条件
1: SOCl2 / 0.5 h / Heating 2: Et3N / CHCl3 / 2 h / Ambient temperature View Scheme
参考文献
Sakaguchi; Nishino; Ogawa; Iwanaga; Yasuda; Kato; Ito
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 1 p. 202 - 211
反应条件
1.1: 99 percent / thionyl chloride; urea / toluene / 3 h / 100 °C 2.1: magnesium; ethanol / toluene; CCl4 / 1 h / Heating 2.2: 95 percent / toluene; CCl4 / 0.5 h / 20 °C 3.1: 5 percent / p-TsOH*H2O / H2O / 7 h / Heating View Scheme
参考文献
Cragg, John E.; Herbert, Richard B.; Jackson, Frederick B.; Moody, Christopher J.; Nicolson, Ian T.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , # 10 p. 2477 - 2486
反应条件
1: Br2 / acetic acid; H2O 3: H2SO4 / Heating 4: LiAlH4 / diethyl ether 5: SOCl2 / pyridine; benzene View Scheme
参考文献
Laurenco,C.; Villien,L.
Tetrahedron, 1984 , vol. 40, p. 2731
