3,4-二甲氧基苯甲酸合成路线 （共 364 条）
参考文献
Sugasawa; Shigehara
Yakugaku Zasshi, 1942 , vol. 62, p. 532; engl. Ref. S. 169
Chem.Abstr., 1951 , p. 2861
反应条件
1: SOCl2 / dioxane / 3 h / Heating 2: 0.658 g / NH3 / dioxane / 12 h 3: 97 percent / Pd2(dba)3; Cs2CO3; XANTPHOS / dioxane / 17 h / 110 °C View Scheme
参考文献
Harayama, Takashi; Toko, Hiroko; Hori, Akihiro; Miyagoe, Taeko; Sato, Tomonori; Nishioka, Hiromi; Abe, Hitoshi; Takeuchi, Yasuo
Heterocycles, 2003 , vol. 61, p. 513 - 520
反应条件
iodine; N-ethyl-N,N-diisopropylamine; triphenylphosphine in dichloromethane T=0 - 20°C; 2 h;
参考文献
Kumar, Amit; Akula, Hari Kiran; Lakshman, Mahesh K.
European Journal of Organic Chemistry, 2010 , # 14 p. 2709 - 2715
反应条件
1: polyphosphoric acid / 1 h / 80 °C 2: triethylsilane; trifluoroacetic acid / 20 °C 3: boron tribromide / dichloromethane / 4 h / 20 °C / Cooling with ice View Scheme
参考文献
Balaydin, Halis Tuerker; Durdagi, Serdar; Ekinci, Deniz; Sentuerk, Murat; Goeksu, Sueleyman; Menzek, Abdullah
Journal of Enzyme Inhibition and Medicinal Chemistry, 2012 , vol. 27, # 4 p. 467 - 475
反应条件
1: 74 percent / CF3SO3H; IPy2BF4 / CH2Cl2 / 0.5 h View Scheme
参考文献
Tetrahedron, , vol. 59, # 36 p. 7231 - 7243
反应条件
1: sulfuric acid / Reflux 2: nitric acid; acetic acid / 0 - 5 °C 3: 10 palladium on activated charcoal; hydrogen 4: 160 - 170 °C 5: methanesulfonic acid; [35S]-L-(-)-Methionine / 120 °C 6: pyridine; 4-(N,N-dimethlyamino)pyridine / 100 °C View Scheme
参考文献
Chen, Yurong; Feng, Man; Li, Shilei; Xu, Jingli; Ning, Hongyu; He, Yong; Wang, Xiao; Ding, Rui; Qi, Chuanmin
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 14 p. 4745 - 4749
反应条件
1: sulfuric acid / Reflux 2: nitric acid; acetic acid / 0 - 5 °C 3: 10 palladium on activated charcoal; hydrogen 4: 160 - 170 °C 5: methanesulfonic acid; [35S]-L-(-)-Methionine / 120 °C 6: pyridine; 4-(N,N-dimethlyamino)pyridine / 100 °C 7: trichlorophosphate / toluene / Reflux 8: pyridine / isopropyl alcohol / Reflux 9: water; sodium hydroxide / methanol View Scheme
参考文献
Chen, Yurong; Feng, Man; Li, Shilei; Xu, Jingli; Ning, Hongyu; He, Yong; Wang, Xiao; Ding, Rui; Qi, Chuanmin
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 14 p. 4745 - 4749
反应条件
1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 1.5 h / 0 °C / Inert atmosphere 2: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere 3: lithium hexamethyldisilazane / tetrahydrofuran / -30 - 0 °C / Inert atmosphere 4: trifluoroacetic acid / methanol / 24 h / 50 °C 5: AlCl3, aluminium chloride; ethanethiol / CHCl2 / 0 - 20 °C View Scheme
参考文献
Chemical Communications, , vol. 47, # 10 p. 2868 - 2870
反应条件
1: sulfuric acid / Reflux 2: nitric acid; acetic acid / 0 - 5 °C 3: 10 palladium on activated charcoal; hydrogen View Scheme
参考文献
Chen, Yurong; Feng, Man; Li, Shilei; Xu, Jingli; Ning, Hongyu; He, Yong; Wang, Xiao; Ding, Rui; Qi, Chuanmin
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 14 p. 4745 - 4749
反应条件
1: sulfuric acid / Reflux 2: nitric acid; acetic acid / 0 - 5 °C 3: 10 palladium on activated charcoal; hydrogen 4: 160 - 170 °C 5: methanesulfonic acid; [35S]-L-(-)-Methionine / 120 °C View Scheme
参考文献
Chen, Yurong; Feng, Man; Li, Shilei; Xu, Jingli; Ning, Hongyu; He, Yong; Wang, Xiao; Ding, Rui; Qi, Chuanmin
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 14 p. 4745 - 4749
