3,4-二甲氧基苯甲酸合成路线 （共 364 条）
反应条件
1: sulfuric acid / Reflux 2: nitric acid; acetic acid / 0 - 5 °C 3: 10 palladium on activated charcoal; hydrogen 4: 160 - 170 °C 5: methanesulfonic acid; [35S]-L-(-)-Methionine / 120 °C 6: pyridine; 4-(N,N-dimethlyamino)pyridine / 100 °C 7: trichlorophosphate / toluene / Reflux View Scheme
参考文献
Chen, Yurong; Feng, Man; Li, Shilei; Xu, Jingli; Ning, Hongyu; He, Yong; Wang, Xiao; Ding, Rui; Qi, Chuanmin
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 14 p. 4745 - 4749
反应条件
sulfuric acid 4 h; Reflux;
参考文献
Murty; Ram, Kesur R.; Rao, Rayudu Venkateswara; Yadav; Rao, Janapala Venkateswara; Pamanji; Velatooru
Letters in Drug Design and Discovery, 2012 , vol. 9, # 3 p. 276 - 281
反应条件
1: SOCl2 / benzene / 24 h / Heating 2: benzene / 24 h / Heating View Scheme
参考文献
Douglas, Christopher J.; Sklenicka, Heather M.; Shen, Hong C.; Mathias, David S.; Degen, Shane J.; Golding, Geoffrey M.; Morgan, Christopher D.; Shih, Regina A.; Mueller, Kristen L.; Seurer, Lisa M.; Johnson, Erik W.; Hsung, Richard P.
Tetrahedron, 1999 , vol. 55, # 48 p. 13683 - 13696
反应条件
tetra-(n-butyl)ammonium iodide; potassium carbonate in acetone
参考文献
Koufaki, Maria; Kiziridi, Christina; Nikoloudaki, Faidra; Alexis, Michael N.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 15 p. 4223 - 4227
反应条件
N'',N'''''-1,8-naphthalenediyl-bis[N,N,N',N'-tetramethyl]-guanidine in N,N-dimethyl-formamide T=20°C; Kinetics;
参考文献
Gholamipour-Shirazi, Azarmidokht; Rolando, Christian
Organic Process Research and Development, 2012 , vol. 16, # 5 p. 811 - 818
参考文献
Hirshberg et al.
Journal of the Chemical Society, 1951 , p. 1030,1033
Full Text Show Details
Homberger, Katharina; Hesse, Manfred
Helvetica Chimica Acta, 1984 , vol. <1> 67, # 29 p. 237 - 248
反应条件
1.1: 2,2,6,6-tetramethylpiperidinyl-lithium 2.1: lithium aluminium tetrahydride / tetrahydrofuran 3.1: potassium tert-butylate / N,N-dimethyl-formamide / 20 °C 4.1: acetic anhydride; sodium carbonate / acetic acid / Reflux 4.2: Reflux 5.1: potassium carbonate / acetone / 24 h / 20 °C View Scheme
参考文献
Le, Tin Thanh; Chau, Nguyet Trang Thanh; Nguyen, Tai Tan; Brien, Josselin; Thai, Trieu Tien; Nourry, Arnaud; Castanet, Anne-Sophie; Nguyen, Kim Phi Phung; Mortier, Jacques
Journal of Organic Chemistry, 2011 , vol. 76, # 2 p. 601 - 608
反应条件
1.1: 2,2,6,6-tetramethylpiperidinyl-lithium 2.1: lithium aluminium tetrahydride / tetrahydrofuran 3.1: potassium tert-butylate / N,N-dimethyl-formamide / 20 °C 4.1: acetic anhydride; sodium carbonate / acetic acid / Reflux 4.2: Reflux 5.1: potassium carbonate / acetone / 24 h / 20 °C 6.1: potassium hydroxide / water / Reflux View Scheme
参考文献
Le, Tin Thanh; Chau, Nguyet Trang Thanh; Nguyen, Tai Tan; Brien, Josselin; Thai, Trieu Tien; Nourry, Arnaud; Castanet, Anne-Sophie; Nguyen, Kim Phi Phung; Mortier, Jacques
Journal of Organic Chemistry, 2011 , vol. 76, # 2 p. 601 - 608
反应条件
1.1: 2,2,6,6-tetramethylpiperidinyl-lithium 2.1: lithium aluminium tetrahydride / tetrahydrofuran 3.1: potassium tert-butylate / N,N-dimethyl-formamide / 20 °C 4.1: acetic anhydride; sodium carbonate / acetic acid / Reflux 4.2: Reflux View Scheme
参考文献
Le, Tin Thanh; Chau, Nguyet Trang Thanh; Nguyen, Tai Tan; Brien, Josselin; Thai, Trieu Tien; Nourry, Arnaud; Castanet, Anne-Sophie; Nguyen, Kim Phi Phung; Mortier, Jacques
Journal of Organic Chemistry, 2011 , vol. 76, # 2 p. 601 - 608
反应条件
1.1: 2,2,6,6-tetramethylpiperidinyl-lithium 2.1: lithium aluminium tetrahydride / tetrahydrofuran 3.1: potassium tert-butylate / N,N-dimethyl-formamide / 20 °C 4.1: acetic anhydride; sodium carbonate / acetic acid / Reflux 4.2: Reflux 5.1: potassium carbonate / acetone / 24 h / 20 °C 6.1: potassium hydroxide / water / Reflux 7.1: 2,2,6,6-tetramethylpiperidinyl-lithium / tetrahydrofuran / 0 - 20 °C 7.2: 2 h / 20 °C View Scheme
参考文献
Le, Tin Thanh; Chau, Nguyet Trang Thanh; Nguyen, Tai Tan; Brien, Josselin; Thai, Trieu Tien; Nourry, Arnaud; Castanet, Anne-Sophie; Nguyen, Kim Phi Phung; Mortier, Jacques
Journal of Organic Chemistry, 2011 , vol. 76, # 2 p. 601 - 608
