3,4-二甲氧基苯甲酸合成路线 （共 364 条）
反应条件
1: sulfuric acid 2: hydrazine hydrate / ethanol 3: ethanol 4: sodium hydroxide View Scheme
参考文献
Abuo-Rahma, Gamal El-Din A.A.; Abdel-Aziz, Mohamed; Beshr, Eman A.M.; Ali, Taha F.S.
European Journal of Medicinal Chemistry, 2014 , vol. 71, p. 185 - 198
反应条件
1: phenyliodine(III)diacetate (PIDA); I2; H2SO4 / acetic acid; acetic anhydride / 20 °C 2: SOCl2 / toluene / Heating View Scheme
参考文献
Serna, Sonia; Tellitu, Imanol; Dominguez, Esther; Moreno, Isabel; SanMartin, Raul
Tetrahedron Letters, 2003 , vol. 44, # 17 p. 3483 - 3486
反应条件
1: DCC / CH2Cl2
2: 84 percent / 6.5 h / Heating
3: 93 percent / toluene-p-sulfonic acid monohydrate / toluene / 0.67 h / Heating
View Scheme
参考文献
Lee, Albert, W. M.; Chan, Wing Hong; Chan, Eddy T. T.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 3 p. 309 - 310
反应条件
1: 77 percent / polyphosphoric acid / 0.5 h / 80 °C
2: 81 percent / hydrogen / Pd/C / acetic acid / 72 h / 20 °C / 4500.45 Torr
View Scheme
参考文献
Jiang, Bo; Shi, Dayong; Cui, Yongchao; Guo, Shuju
Archiv der Pharmazie, 2012 , vol. 345, # 6 p. 444 - 453
参考文献
Tiemann; Matsmoto
Chemische Berichte, 1876 , vol. 9, p. 939
Chemische Berichte, 1878 , vol. 11, p. 131
反应条件
1: methanesulfonic acid / CH2Cl2 / 4 h / -20 - 0 °C
2: 1.92 g / CH2Cl2 / 18.5 h / -20 - 18 °C
View Scheme
参考文献
Mattson, Matthew N.; Rapoport, Henry
Journal of Organic Chemistry, 1996 , vol. 61, # 17 p. 6071 - 6074
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in N,N-dimethyl-formamide
T=60°C; 0.05 h; Microwave irradiation;
参考文献
Kumar, Katari Naresh; Sreeramamurthy, Kintali; Palle, Sadananda; Mukkanti, Khagga; Das, Parthasarathi
Tetrahedron Letters, 2010 , vol. 51, # 6 p. 899 - 902
反应条件
diphosphorous tetraiodide in tetrachloromethane; dichloromethane
Heating;
参考文献
Suzuki, Hitomi; Tsuji, Junko; Sato, Naofumi; Osuka, Atsuhiro
Chemistry Letters, 1983 , p. 449 - 452
反应条件
1: thionyl chloride / 2.5 h / 80 °C
2: 10percent sodium hydroxyde / diethyl ether / 0.5 h / 0 °C
View Scheme
参考文献
Gore, Vinayak G.; Narasimhan, Nurani S.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 481 - 484
反应条件
1: 3,4-dimethoxy-benzoic acid With n-butyllithium; potassium tert-butylate in tetrahydrofuran; hexane
T=-78 - -50°C; 2 h;
2: methyl iodide in tetrahydrofuran; hexane
T=-78 - 20°C; Further stages.;
参考文献
Chau, Nguyet Trang Thanh; Nguyen, Thi Huu; Castanet, Anne-Sophie; Nguyen, Kim Phi Phung; Mortier, Jacques
Tetrahedron, 2008 , vol. 64, # 46 p. 10552 - 10557
