3,4-二甲氧基苯甲酸合成路线 （共 364 条）
反应条件
1: sec.-butyllithium; 3,4-dimethoxy-benzoic acid With N,N,N',N,-tetramethylethylenediamine in tetrahydrofuran; hexane; cyclohexane
T=-78 - -30°C; 2 h;
2: methyl iodide in tetrahydrofuran; hexane; cyclohexane
T=-30 - 20°C; Further stages.;
参考文献
Chau, Nguyet Trang Thanh; Nguyen, Thi Huu; Castanet, Anne-Sophie; Nguyen, Kim Phi Phung; Mortier, Jacques
Tetrahedron, 2008 , vol. 64, # 46 p. 10552 - 10557
反应条件
1: carbon disulfide; phosphorus pentachloride
2: AlCl3
View Scheme
参考文献
v. Kostanecki; Tambor
Chemische Berichte, 1906 , vol. 39, p. 4023
反应条件
1: DCC / CH2Cl2
2: 84 percent / 6.5 h / Heating
3: 48 percent / trichloroacetic acid / benzene / 0.7 h / Heating
4: 49 percent / Raney-Ni / ethanol
View Scheme
参考文献
Lee, Albert, W. M.; Chan, Wing Hong; Chan, Eddy T. T.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 3 p. 309 - 310
反应条件
1: 3,4-dimethoxy-benzoic acid With NbCl5 in dichloromethane
2: diethylamine in dichloromethane
T=45 - 50°C; 8 h;
参考文献
Nery, Marcelo S.; Ribeiro, Renata P.; Lopes, Claudio C.; Lopes, Rosangela S. C.
Synthesis, 2003 , # 2 p. 272 - 276
反应条件
1: SOCl2 / Ambient temperature
2: CH2Cl2 / 3 h / Ambient temperature
View Scheme
参考文献
Khaldi, Mustapha
Bulletin de la Societe Chimique de France, 1996 , vol. 133, # 1 p. 7 - 13
反应条件
1: thionyl chloride, pyridine / benzene / 0.5 h / Heating
2: 2.) NH4Cl, 28percent aq. NH4OH / 1.) ether, reflux, 3 h, 2.) 100 deg C
View Scheme
参考文献
Toda, Jun; Niimura, Yoshihiro; Takeda, Kaoru; Sano, Takehiro; Tsuda, Yoshisuke
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 6 p. 906 - 912
反应条件
Yield given. Multistep reaction;
参考文献
Bassoli, Angela; Gregorio, Giuseppina Di; Rindone, Bruno; Tollari, Stefano; Chioccara, Francesco; Salmona, Mario
Gazzetta Chimica Italiana, 1988 , vol. 118, # 11 p. 763 - 768
反应条件
N,N,N',N,-tetramethylethylenediamine; methyl iodide in tetrahydrofuran; hexane; cyclohexane
T=-30 - 20°C;
参考文献
Chau, Nguyet Trang Thanh; Nguyen, Thi Huu; Castanet, Anne-Sophie; Nguyen, Kim Phi Phung; Mortier, Jacques
Tetrahedron, 2008 , vol. 64, # 46 p. 10552 - 10557
反应条件
1: sec.-butyllithium; 3,4-dimethoxy-benzoic acid With N,N,N',N,-tetramethylethylenediamine in tetrahydrofuran; hexane; cyclohexane
T=-78 - -30°C; 2 h;
2: methyl iodide in tetrahydrofuran; hexane; cyclohexane
T=-30 - 20°C; Further stages.;
参考文献
Chau, Nguyet Trang Thanh; Nguyen, Thi Huu; Castanet, Anne-Sophie; Nguyen, Kim Phi Phung; Mortier, Jacques
Tetrahedron, 2008 , vol. 64, # 46 p. 10552 - 10557
反应条件
1: thionyl chloride / 2 h / Reflux
2: pyridine / dichloromethane / -20 - 20 °C
View Scheme
参考文献
PROTEOTECH INC; ESPOSITO, Luke; YADON, Marisa, C.; CUMMINGS, Joel; HUDSON, F., Michael; LAKE, Thomas; HEFTI, Franz, F.; GOLDING, Geoffrey; CHOI, Seok-Rye; LI, Ximin; SNOW, Alan, D.; QUBAI, Hu; JUDY, Cam
Patent: WO2012/118935 A1, 2012 ;
