3,4-二甲氧基苯甲酸合成路线 （共 364 条）
反应条件
sulfuric acid
Reflux;
参考文献
Narasimhan, Balasubramanian; Ohlan, Sucheta; Ohlan, Ruchita; Judge, Vikramjeet; Narang, Rakesh
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 2 p. 689 - 700
反应条件
1: Br2 / acetic acid; H2O
3: H2SO4 / Heating
4: LiAlH4 / diethyl ether
5: SOCl2 / pyridine; benzene
6: 73 percent / acetonitrile / 4 h / Heating
7: 30 percent / (Et2AlH2)Na / toluene; tetrahydrofuran / 4 h / Ambient temperature
View Scheme
参考文献
Laurenco,C.; Villien,L.
Tetrahedron, 1984 , vol. 40, p. 2731
反应条件
sulfuric acid; acetic acid
T=50°C; 5 h;
参考文献
Ni, Jizhi; Xiao, Heping; Weng, Lipeng; Wei, Xiaofeng; Xu, Youjun
Tetrahedron, 2011 , vol. 67, # 29 p. 5162 - 5167
反应条件
1: phosphorus pentachloride
2: pyridine
3: pyridine; potassium hydroxide
View Scheme
参考文献
Joshi, Akshada J.; Gadhwal, Manoj K.; Joshi, Urmila J.; D'Mello, Priscilla; Sinha, Ragini; Govil, Girjesh
Medicinal Chemistry Research, 2013 , vol. 22, # 9 p. 4293 - 4299
反应条件
1: With hydrogenchloride in water
T=15°C; 8 h;
2: With lithium aluminium tetrahydride in tetrahydrofuran
4 h; Heating;
3: With manganese(IV) oxide in dichloromethane
T=25°C; 24 h;
参考文献
Meziane, Mohamed Ameziane Ait Amer; Bazureau, Jean Pierre
Molecules, 2002 , vol. 7, # 2 p. 252 - 263
反应条件
1: 89 percent / HCl; NH4OH / 20 h / 15 - 30 °C
2: 85 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating
3: 98 percent / MnO2 / CH2Cl2 / 24 h / 25 °C
View Scheme
参考文献
Ameur Meziane, Mohamed Ait; Royer, Sylvain; Bazureau, Jean Pierre
Tetrahedron Letters, 2001 , vol. 42, # 6 p. 1017 - 1020
反应条件
1.1: thionyl chloride / dichloromethane / 0.5 h / 25 °C
1.2: 2 h / 25 °C
2.1: potassium tert-butylate / dimethyl sulfoxide / 0.17 h / 10 °C
2.2: 8 h / 10 - 20 °C
View Scheme
参考文献
Agarwal, Piyush K.; Dathi, Meena D.; Saifuddin, Mohammad; Kundu, Bijoy
Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 1901 - 1908
反应条件
1: hydrobromic acid
2: chloroform; NaOH-solution
3: sodium methylate / 100 °C / im Rohr und Hydrolyse des Reaktionsprodukts mit methylalkoholischer Kalilauge
View Scheme
参考文献
Perkin; Stoyle
Journal of the Chemical Society, 1923 , vol. 123, p. 3174
反应条件
1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane
2: hydrazine hydrate / dichloromethane
3: Lawesson's reagent / toluene / 3 h / 100 °C
View Scheme
参考文献
PROTEOTECH INC; ESPOSITO, Luke; YADON, Marisa, C.; CUMMINGS, Joel; HUDSON, F., Michael; LAKE, Thomas; HEFTI, Franz, F.; GOLDING, Geoffrey; CHOI, Seok-Rye; LI, Ximin; SNOW, Alan, D.; QUBAI, Hu; JUDY, Cam
Patent: WO2012/118935 A1, 2012 ;
反应条件
hydrogenchloride; ammonium hydroxide
T=15 - 30°C; 20 h;
参考文献
Ameur Meziane, Mohamed Ait; Royer, Sylvain; Bazureau, Jean Pierre
Tetrahedron Letters, 2001 , vol. 42, # 6 p. 1017 - 1020
