3,4-二甲氧基苯甲酸合成路线 （共 364 条）
反应条件
1: 98 percent / oxalyl chloride / benzene; dimethylformamide / 2 h / Ambient temperature
2: 1.) sodium wire / 1) ether; 2) ether, reflux, 5 h
3: 86 percent / sodium acetate / aq. ethanol / 6 h / Heating
4: 67 percent / aq. KOH / 40 h / Ambient temperature
5: 51 percent
View Scheme
参考文献
Cragg, John E.; Herbert, Richard B.; Jackson, Frederick B.; Moody, Christopher J.; Nicolson, Ian T.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , # 10 p. 2477 - 2486
反应条件
1: 98 percent / oxalyl chloride / benzene; dimethylformamide / 2 h / Ambient temperature
2: 1.) sodium wire / 1) ether; 2) ether, reflux, 5 h
3: 86 percent / sodium acetate / aq. ethanol / 6 h / Heating
4: 67 percent / aq. KOH / 40 h / Ambient temperature
View Scheme
参考文献
Cragg, John E.; Herbert, Richard B.; Jackson, Frederick B.; Moody, Christopher J.; Nicolson, Ian T.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , # 10 p. 2477 - 2486
反应条件
1: polyphosphoric acid / 1 h / 80 °C
2: boron tribromide / dichloromethane / 4 h / 20 °C / Cooling with ice
View Scheme
参考文献
Balaydin, Halis Tuerker; Durdagi, Serdar; Ekinci, Deniz; Sentuerk, Murat; Goeksu, Sueleyman; Menzek, Abdullah
Journal of Enzyme Inhibition and Medicinal Chemistry, 2012 , vol. 27, # 4 p. 467 - 475
反应条件
1: polyphosphoric acid / 1.5 h / 80 °C
2: boron tribromide / dichloromethane / 24 h / 0 - 25 °C / Inert atmosphere
View Scheme
参考文献
Cetinkaya, Yasin; Goecer, Huelya; Menzek, Abdullah; Guelcin, Ilhami
Archiv der Pharmazie, 2012 , vol. 345, # 4 p. 323 - 334
反应条件
1: thionyl chloride / CH2Cl2 / 1 h / Heating
2: 52 percent / pyridine / 2 h / 0 °C
View Scheme
参考文献
Terada; Motomiya; Yoshioka; Narita; Yasui; Takase
Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 6 p. 2437 - 2442
反应条件
1: 2,2,6,6-tetramethylpiperidinyl-lithium
2: lithium aluminium tetrahydride / tetrahydrofuran
View Scheme
参考文献
Le, Tin Thanh; Chau, Nguyet Trang Thanh; Nguyen, Tai Tan; Brien, Josselin; Thai, Trieu Tien; Nourry, Arnaud; Castanet, Anne-Sophie; Nguyen, Kim Phi Phung; Mortier, Jacques
Journal of Organic Chemistry, 2011 , vol. 76, # 2 p. 601 - 608
反应条件
1: With n-butyllithium; 2,2,6,6-tetramethylpiperidinyl-lithium in tetrahydrofuran; hexane
T=-78 - 0°C;
2: With iodine in tetrahydrofuran; hexane
1 h; Heating; Further stages.;
参考文献
Chau, Nguyet Trang Thanh; Nguyen, Thi Huu; Castanet, Anne-Sophie; Nguyen, Kim Phi Phung; Mortier, Jacques
Tetrahedron, 2008 , vol. 64, # 46 p. 10552 - 10557
反应条件
1: With trichlorophosphate
T=75°C; 1 h;
2: With water
T=20°C; 4 h; Reflux;
参考文献
Alegaon, Shankar G.; Alagawadi, Kallanagouda R.
Medicinal Chemistry Research, 2012 , vol. 21, # 6 p. 816 - 824
反应条件
polyphosphoric acid
T=80°C; 2 h;
参考文献
Jiang, Bo; Shi, Dayong; Cui, Yongchao; Guo, Shuju
Archiv der Pharmazie, 2012 , vol. 345, # 6 p. 444 - 453
反应条件
1: carbon disulfide; phosphorus pentachloride
2: aluminium chloride
View Scheme
参考文献
v. Kostanecki; Tambor
Chemische Berichte, 1906 , vol. 39, p. 4023
