3,4-二甲氧基苯甲酸合成路线 （共 364 条）
反应条件
1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / Cooling with ice
2: triethylamine / dichloromethane / 3 h / 20 °C
3: sodium hydride / N,N-dimethyl-formamide / 0.25 h / Cooling with ice
4: palladium diacetate; potassium carbonate / N,N-dimethyl-formamide / Inert atmosphere; Reflux
View Scheme
参考文献
Harayama, Takashi; Nagura, Chie; Miyagoe, Taeko; Kawata, Yuko; Abe, Hitoshi; Takeuchi, Yasuo
Heterocycles, 2010 , vol. 81, # 11 p. 2609 - 2616
反应条件
1: (COCl)2; DMF / CH2Cl2
2: diethyl ether / 0 °C
View Scheme
参考文献
Young, Jonathan R.; Huang, Song X.; Chen, Irene; Walsh, Thomas F.; DeVita, Robert J.; Wyvratt Jr., Matthew J.; Goulet, Mark T.; Ren, Ning; Lo, Jane; Yang, Yi Tien; Yudkovitz, Joel B.; Cheng, Kang; Smith, Roy G.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 15 p. 1723 - 1727
反应条件
1: 88 percent / conc. H2SO4 / 3 h / Heating
2: 53 percent / NaH / benzene / 2 h
View Scheme
参考文献
Choshi; horimoto; Wang; Nagase; Ichikawa; Sugino; Hibino
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 4 p. 1047 - 1049
反应条件
1: 3,4-dimethoxy-benzoic acid With n-butyllithium; 2,2,6,6-tetramethylpiperidinyl-lithium in tetrahydrofuran; hexane
T=-78 - 0°C;
2: carbon dioxide in tetrahydrofuran; hexane
1 h; Heating; Further stages.;
参考文献
Chau, Nguyet Trang Thanh; Nguyen, Thi Huu; Castanet, Anne-Sophie; Nguyen, Kim Phi Phung; Mortier, Jacques
Tetrahedron, 2008 , vol. 64, # 46 p. 10552 - 10557
