1: (S)-1,2,3,4-tetrahydro-2-naphthoic acid With 1,1'-carbonyldiimidazole in tetrahydrofuran T=20°C; 2: malonic acid ethyl ester monopotassium salt With triethylamine; magnesium chloride in tetrahydrofuran; acetonitrile T=20°C; Cooling with ice; 3: With hydrogenchloride; water in toluene T=20°C; Cooling with ice;
参考文献
PRONOXIS AB; Wallner, Karl Fredrik; Olofsson, Jan Peter; Hultqvist, Malin Kristin; Pelcman, Benjamin Harry
Patent: US2014/18384 A1, 2014 ;
Location in patent: Paragraph 0124 ;