(3,4-二甲氧苯基)乙腈合成路线 （共 124 条）
反应条件
1: 88 percent / anhydrous hydrogen chloride
2: 97 percent / liquid NH3 / ethanol / 1) -50 deg C, 2) 0 deg C, 2 h
View Scheme
参考文献
Niewohner, Ulrich; Schauss, Dagmar; Hendrix, Martin; Konig, Gerhard; Boss, Frank-Gerhard; Staay, Franz-Josef Van Der; Schreiber, Rudy; Schlemmer, Karl-Heinz; Grosser, Rolf
Patent: US2002/198377 A1, 2002 ;
反应条件
sodium ethanolate in ethanol
参考文献
Ikeda, Takashi; Yaegashi, Takashi; Matsuzaki, Takeshi; Hashimoto, Syusuke; Sawada, Seigo
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 1 p. 342 - 345
反应条件
1: With methanesulfonic acid; zinc in tetrahydrofuran
Blaise reaction; 0.5 h;
2: With hydrogenchloride in tetrahydrofuran
参考文献
Shin, Hyunik; Choi, Bo Seung; Lee, Ki Kon; Choi, Hyeong-Wook; Chang, Jay Hyok; Lee, Kyu Woong; Nam, Do Hyun; Kim, No-Soo
Synthesis, 2004 , # 16 p. 2629 - 2632
反应条件
1: 1.) LDA
2: I2, KI, sat. NaHCO3
3: 1.) aq. NaOH; 2.) aq. HCl
4: 1.) aq. NaOH; 2.) NaIO4
5: NaBH4
6: 73 percent / O2 / Pd
7: t-BuOK / tetrahydrofuran
8: 7 percent / H2O / 180 °C
View Scheme
参考文献
Takano, Seiichi; Imamura, Yoko; Ogasawara, Kunio
Chemistry Letters, 1981 , p. 1385 - 1386
反应条件
sodium t-butanolate in pyridine
3 h; Heating;
参考文献
Volovenko, Yu. M.; Litenko, V. A.; Dashkovskaya, E. V.; Babichev, F. S.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1982 , vol. 18, # 8 p. 796 - 798
Khimiya Geterotsiklicheskikh Soedinenii, 1982 , vol. 18, # 8 p. 1047 - 1048
反应条件
1: TEBA; aq. KOH / 48 h / 20 °C
2: 0.76 g / KOH; ethylene glycol / Heating
View Scheme
参考文献
Buchholz, Mirko; Heiser, Ulrich; Schilling, Stephan; Niestroj, Andre J.; Zunkel, Katrin; Demuth, Hans-Ulrich
Journal of Medicinal Chemistry, 2006 , vol. 49, # 2 p. 664 - 677
反应条件
hydrogenchloride; diethyl ether; zinc(II) chloride
beim Erwaermen des Reaktionsprodukts mit H2O;
参考文献
Mascayano, Carolina; Rezende, Marcos Caroli; Rivera, Yenifer; Espinosa, Victoria
Journal of the Chilean Chemical Society, 2011 , vol. 56, # 4 p. 935 - 937
反应条件
1: ZnCl2, HCl gas / diethyl ether / 0 °C / overnight
2: H2O / 2 h / Heating
View Scheme
参考文献
Jain, Amolak C.; Prasad, Ashok K.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988 , vol. 27, # 1-12 p. 622 - 624
反应条件
1: NaOEt / ethanol / 1)reflux 3.5h 2)stand overnight
2: HCl / acetic acid; H2O / 1)35 - 50 deg C 2)room temp., 48h
3: 80 percent / 10percentHCl / 6 h / Heating
4: 100 percent / NaBH4 / ethanol / 5 h / Heating
5: 89 percent / SOCl2 / benzene / 1.5 h / Heating
View Scheme
参考文献
Valenta; Dlabac; Valchar; Protiva
Collection of Czechoslovak Chemical Communications, 1984 , vol. 49, # 4 p. 1002 - 1008
反应条件
potassium hydroxide in methanol; water; benzene
3 h; Ambient temperature;
参考文献
Vejdelek, Zdenek; Holubek, Jiri; Budesinsky, Milos; Ryska, Miroslav; Svatek, Emil; Protiva, Miroslav
Collection of Czechoslovak Chemical Communications, 1988 , vol. 53, # 2 p. 361 - 372
