(3,4-二甲氧苯基)乙腈合成路线 （共 124 条）
反应条件
1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C
1.2: 0.33 h / -78 °C
1.3: 1 h / 22 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 80 °C
View Scheme
参考文献
Singh, Kawaljit; Kumar, Malkeet; Pavadai, Elumalai; Naran, Krupa; Warner, Digby F.; Ruminski, Peter G.; Chibale, Kelly
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 14 p. 2985 - 2990
反应条件
aluminium trichloride in nitrobenzene
T=80°C; 5 h; also with BBr3, other solvents, temperatures, and times; Product distribution;
参考文献
Szantay; Dornyei; Blasko; et al.
Archiv der Pharmazie, 1981 , vol. 314, # 12 p. 983 - 991
反应条件
1: With hydrogenchloride; zinc(II) chloride in diethyl ether
T=0 - 20°C;
2: With water in methanol
5 h; Reflux;
参考文献
Ng, Lean-Teik; Ko, Horng-Huey; Lu, Tzy-Ming
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 13 p. 4360 - 4366
反应条件
1: ZnCl2; HCl / diethyl ether
2: BF3-etherate; MeSO2Cl / 100 °C
View Scheme
参考文献
Bondarenko; Levenets; Frasinyuk; Khilya
Chemistry of Natural Compounds, 2003 , vol. 39, # 3 p. 271 - 275
反应条件
1: 88 percent / anhydrous hydrogen chloride
2: 1,2-dimethoxy-ethane / Ambient temperature
3: 1) CH3SO3H, 2) 25percent NaOH / 1) acetic acid, rt, 2) TFA, 48percent H2SO4
View Scheme
参考文献
Robey; Copley-Merriman; Phelps
Journal of Heterocyclic Chemistry, 1989 , vol. 26, # 3 p. 779 - 783
反应条件
N-benzyl-trimethylammonium hydroxide in tert-butyl alcohol
参考文献
Koyama, Junko; Sugita, Teruyo; Suzuta, Yukio; Irie, Hiroshi
Heterocycles, 1981 , vol. 16, # 6 p. 969 - 972
反应条件
magnesium sulfate in methanol; ethyl acetate; tert-butyl alcohol
参考文献
Rorer Pharmaceutical Corporation
Patent: US4795757 A1, 1989 ;
反应条件
1: methanol. KOH; tert-butyl alcohol
2: methanol. HCl
View Scheme
参考文献
Horning et al.
Journal of the American Chemical Society, 1952 , vol. 74, p. 773
反应条件
1: methanol. KOH; tert-butyl alcohol
2: methanol. HCl
3: potassium-sodium-alloy; toluene / anschliessendes Behandeln mit wss. HCl und Essigsaeure
4: toluene; benzenesulfonic acid / unter Entfernen des entstehenden Wassers
View Scheme
参考文献
Horning et al.
Journal of the American Chemical Society, 1952 , vol. 74, p. 773
反应条件
aluminium hydride-d3 in tetrahydrofuran
T=0 - 20°C; 32 h;
参考文献
Rampe; Hake; Borretzen; Holm; Skattebol
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 3 p. 259 - 263
