(3,4-二甲氧苯基)乙腈合成路线 （共 124 条）
反应条件
n-butyllithium in diethyl ether 1.) -70 deg C, 2 h, 2.) -70 deg C, 2 h; r.t., 12 h; Yields of byproduct given;
参考文献
Refat, Hala Mohammed; Faddo, Ahmed A.; Biehl, Ed
Journal of Fluorine Chemistry, 1996 , vol. 76, # 1 p. 99 - 103
反应条件
1: 81 percent / 50percent aq. NaOH, Bu4NHSO4 / 5 h / 45 - 60 °C 2: 70 percent / NaNH2 / toluene / 5 h / Heating 3: oxalic acid / acetone; H2O / 3 h / 40 °C View Scheme
参考文献
Butora, Gabriel; Blaha, Ludvik; Rajsner, Miroslav; Helfert, Ivan
Collection of Czechoslovak Chemical Communications, 1992 , vol. 57, # 9 p. 1967 - 1981
反应条件
hydrogenchloride; diethyl ether; zinc(II) chloride Erwaermen des Reaktionsprodukts mit Wasser;
参考文献
Boyd; Robertson
Journal of the Chemical Society, 1948 , p. 174
参考文献
Meseri
Rev. Fac. Cienc. quim. Univ. La Plata, 1948 , vol. 23, p. 99,101
反应条件
sodium hydroxide in water; dimethyl sulfoxide T=20°C; 48 h;
参考文献
Wang, Cheng; Wang, Tao; Zhou, Nan; Pan, Xiao-Yan; He, Huai-Zhen
Journal of Asian Natural Products Research, 2014 , vol. 16, # 3 p. 304 - 311
参考文献
Ajinomoto Co., Inc.
Patent: US5231105 A1, 1993 ;
反应条件
potassium hydroxide in water; ethylene glycol 20 h; Heating;
参考文献
Mangla, V. K.; Bhakuni, D. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 9 p. 748 - 749
反应条件
potassium hydroxide in toluene T=160°C; 8 h; microwave irradiation;
参考文献
Tetrahedron, , vol. 64, # 23 p. 5604 - 5619
反应条件
1: sodium ethylate 2: aqueous H2SO4 View Scheme
参考文献
Stein et al.
Journal of the American Chemical Society, 1955 , vol. 77, p. 700,702
反应条件
1: 1.) NaH / 1.) DMF, RT, 5 h, 2.) RT, overnight 2: 94 percent / potassium, Tebac / tetrahydrofuran / 36 h / Heating View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 25, # 4 p. 351 - 359
