(3,4-二甲氧苯基)乙腈合成路线 （共 124 条）
反应条件
n-butyllithium in tetrahydrofuran; diethyl ether 1.) -70 deg C, 2 h, 2.) -70 deg C, 2 h; r.t., 12 h;
参考文献
Refat, Hala Mohammed; Waggenspack, John; Dutt, Mahesh; Zhang, Hongming; Fadda, A. A.; Biehl, Ed
Journal of Organic Chemistry, 1995 , vol. 60, # 7 p. 1985 - 1989
反应条件
1: sodium ethylate 2: aqueous H2SO4 3: <NH4>2CO3 View Scheme
参考文献
Stein et al.
Journal of the American Chemical Society, 1955 , vol. 77, p. 700,702
反应条件
1: NaOH (5mol/l) / H2O; xylene 3: POCl3 / toluene View Scheme
参考文献
Schmauder; Groger; Gruner; Lohmann
Pharmazie, 1988 , vol. 43, # 5 p. 313 - 314
反应条件
tin(IV) chloride T=100 - 120°C;
参考文献
Lora-Tamayo et al.
Chemistry and Industry (London, United Kingdom), 1959 , p. 657
Chemische Berichte, 1960 , vol. 93, p. 289 Anm. 5
Full Text Show Details
Lora-Tamayo; Madronero
Rev.Acad.Cienc.exact.fis.nat.Madrid, 1959 , vol. 53, p. 527,543
反应条件
1: NaOH (5mol/l) / H2O; xylene 3: POCl3 / toluene 4: Pd/Al2O3 / 1,2,3,4-tetrahydro-naphthalene View Scheme
参考文献
Schmauder; Groger; Gruner; Lohmann
Pharmazie, 1988 , vol. 43, # 5 p. 313 - 314
反应条件
potassium hydroxide in toluene T=160°C; 8 h; microwave irradiation;
参考文献
Tetrahedron, , vol. 64, # 23 p. 5604 - 5619
参考文献
Kindler; Peschke
Archiv der Pharmazie (Weinheim, Germany), 1933 , vol. 271, p. 431,435
反应条件
diisobutylaluminium hydride in dichloromethane; cyclohexane T=0°C; 0.25 h;
参考文献
Henrion, Guilhem; Chavas, Thomas E. J.; Le Goff, Xavier; Gagosz, Fabien
Angewandte Chemie - International Edition, 2013 , vol. 52, # 24 p. 6277 - 6282
Angew. Chem., 2013 , vol. 125, # 24 p. 6397 - 6402,6
反应条件
1: 84 percent / sodium hydride / toluene / 41 h / Heating 2: 1.) potassium hydroxide; 2.) 85percent H3PO4 / 1.) ethanol, water, 100 deg C; 2.) water, 115 deg C 3: 71 percent / hydrogen / PtO2 / acetic acid / 10 h / 20 °C / 1551.4 Torr View Scheme
参考文献
Cardellini; Claudi; Perlini; Balduini; Cattabeni; Cimino
Farmaco, Edizione Scientifica, 1987 , vol. 42, # 4 p. 307 - 317
反应条件
1: LDA / tetrahydrofuran / -78 - 20 °C 2: 1.) 10percent KOH-EtOH, 2.) 10percent HCl-EtOH / 1.) reflux over night, 2.) room temperature 3: 1.) lithium diisopropylamide / tetrahydrofuran / from -78 degC up to room temperature 4: c.HCl / ethanol / 3 h / Heating 6: 1.) NaBH4, 2.) acid 7: 73 percent / O2 / PdCl2-CuCl / dimethylformamide / 168 h 8: 66 percent / tetrahydrofuran / Heating 9: 7 percent / H2O / 1 h / 180 °C / sealed tube 10: 77 percent / lithium / liquid ammonia View Scheme
参考文献
Takano, Seiichi; Imamura, Yoko; Ogasawara, Kunio
Tetrahedron Letters, 1981 , vol. 22, # 45 p. 4479 - 4482
