(3,4-二甲氧苯基)乙腈合成路线 （共 124 条）
反应条件
bromine; sodium acetate; acetic acid
参考文献
Richardson et al.
Journal of the Chemical Society, 1937 , p. 835,839
Full Text Show Details
Haworth; Marvin; Sheldrick
Journal of the Chemical Society, 1934 , p. 1423,1427
Journal of the Chemical Society, 1935 , p. 1982
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane 0.166667 h; Heating;
参考文献
Kyong, Dao Hung; Sladkov, V. I.; Suvorov, N. N.
Journal of Organic Chemistry USSR (English Translation), 1987 , vol. 23, # 9 p. 1732 - 1738
Zhurnal Organicheskoi Khimii, 1987 , vol. 23, # 9 p. 1954 - 1961
反应条件
perchloric acid; montmorillonite K10 supported ammonium nitrate T=27°C; 1.25 h;
参考文献
Meshram; Ganesh; Madhavi; Eshwaraiah; Yadav; Gunasekar
Synthetic Communications, 2003 , vol. 33, # 14 p. 2497 - 2503
反应条件
hydrogenchloride; ethanethioamide in N,N-dimethyl-formamide T=100°C; 2 h;
参考文献
Chihiro; Nagamoto; Takemura; Kitano; Komatsu; Sekiguchi; Tabusa; Mori; Tominaga; Yabuuchi
Journal of Medicinal Chemistry, 1995 , vol. 38, # 2 p. 353 - 358
反应条件
1: 89 percent / diisobutylaluminum hydride; methanol / diethyl ether; cyclohexane / 7 h / -70 - 20 °C 2: 52 percent / aq. HBr / 17 h / Heating View Scheme
参考文献
Zuurmond, Helene M.; Hessling, Jutta; Blueml, Klaus; Lohse, Martin; Ijzerman, Adriaan P.
Molecular Pharmacology, 1999 , vol. 56, # 5 p. 909 - 916
反应条件
1.1: NaH / tetrahydrofuran 1.2: tetrahydrofuran 2.1: NH2NH2*HCl / aq. ethanol / Heating View Scheme
参考文献
Chen, Chen; Wilcoxen, Keith M.; Huang, Charles Q.; McCarthy, James R.; Chen, Takung; Grigoriadis, Dimitri E.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 14 p. 3669 - 3673
反应条件
1: acetic acid; concentrated HNO3 2: Raney nickel; ethyl acetate / Hydrogenation 3: Raney nickel; ethyl acetate / Hydrogenation View Scheme
参考文献
Plieninger; Nogradi
Chemische Berichte, 1955 , vol. 88, p. 1961
Full Text Show Details
Walker
Journal of the American Chemical Society, 1955 , vol. 77, p. 3844,3848,6729
反应条件
1: aq.-ethanolic KOH-solution 2: hydrogen chloride View Scheme
参考文献
Kindler; Peschke
Archiv der Pharmazie (Weinheim, Germany), 1933 , vol. 271, p. 431,435
反应条件
1: 74.2 percent / KOH / methanol; H2O / 5 h / Heating 2: oxalyl chloride / benzene / 1 h / Ambient temperature View Scheme
参考文献
Mangla, V. K.; Bhakuni, D. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 9 p. 748 - 749
反应条件
hydrogen; palladium on activated charcoal in acetic acid 4 h;
参考文献
Tetrahedron Letters, , vol. 36, # 14 p. 2497 - 2500
