反应条件
1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; cyclohexane / 1 h / -78 - 20 °C / |Inert atmosphere
1.2: 18 h / -78 - 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 0 - 20 °C
3.1: triphenylphosphine / 0.25 h / 20 °C
3.2: 18 h
4.1: hydrazine / methanol / 18 h
View Scheme
参考文献
Charifson, Paul S.; Cottrell, Kevin Michael; Deng, Hongbo; Duffy, John P.; Gao, Huai; Giroux, Simon; Green, Jeremy; Jackson, Katrina Lee; Kennedy, Joseph M.; Lauffer, David J.; Ledeboer, Mark Willem; Li, Pan; Maxwell, John Patrick; Morris, Mark A.; Pierce, Albert Charles; Waal, Nathan D.; Xu, Jinwang
Patent: US2013/281431 A1, 2013 ;