3,4-二甲氧基苯乙酸合成路线 （共 159 条）
反应条件
1: POCl3 / toluene / 3.5 h / 20 - 120 °C 2: NaBH4 / methanol / 2.5 h / 20 °C View Scheme
参考文献
Kaur, Jaskiran; Ghosh, Narendra Nath; Talwar, Anita; Chandra, Ramesh
Chemical and pharmaceutical bulletin, 2002 , vol. 50, # 9 p. 1223 - 1228
反应条件
iodine cloride in acetic acid T=20°C; 1.5 h;
参考文献
Olivera, Roberto; SanMartin, Raul; Churruca, Fatima; Dominguez, Esther
Journal of Organic Chemistry, 2002 , vol. 67, # 21 p. 7215 - 7225
反应条件
1: 86 percent / ICl / CH2Cl2; acetic acid 2: 92 percent / SOCl2 / 20 °C View Scheme
参考文献
Qandil, Amjad M.; Miller, David W.; Nichols, David E.
Synthesis, 1999 , # 12 p. 2033 - 2035
反应条件
1: oxalyl chloride; DMF / benzene / 2 h / 20 °C 2: 8.0 g / CH2Cl2 / 2 h / 0 - 20 °C 3: 83 percent / Lawesson's reagent / toluene / 5 h / Heating 4: 84 percent / toluene / 18 h / Heating 5: 93 percent / CF3COOH / CH2Cl2 / 48 h / 20 °C 6: 68 percent / Raney nickel / ethanol / 15 h / Heating View Scheme
参考文献
Padwa, Albert; Beall, L. Scott; Heidelbaugh, Todd M.; Liu, Bing; Sheehan, Scott M.
Journal of Organic Chemistry, 2000 , vol. 65, # 9 p. 2684 - 2695
反应条件
sulfuric acid Heating;
参考文献
Kim, Dong-Ick; Kim, Hak-Yeop; Kwon, Lae-Sung; Park, Sung-Dae; Jeon, Gee-Ho; Jung, Kyung-Yun; Min, Jae-Ki; Nam, Woong-Hyun; Lee, Kiho; Chung, You-Sup; Tanabe, Shigeru; Kozono, Toshiro
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 1 p. 85 - 90
反应条件
sulfuric acid in methanol
参考文献
Transitions Optical, Inc.
Patent: US6630597 B1, 2003 ;
参考文献
Shibuya, Masatoshi; Sato, Takahisa; Tomizawa, Masaki; Iwabuchi, Yoshiharu
Chemical Communications, 2009 , # 13 p. 1739 - 1741
参考文献
ICI Pharma; Imperial Chemical Industries PLC
Patent: US5219848 A1, 1993 ;
反应条件
thionyl chloride in dichloromethane
参考文献
Jetter, Michele C.; Youngman, Mark A.; McNally, James J.; McDonnell, Mark E.; Zhang, Sui-Po; Dubin, Adrienne E.; Nasser, Nadia; Codd, Ellen E.; Flores, Christopher M.; Dax, Scott L.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 22 p. 6160 - 6163
反应条件
sodium hydroxide; thionyl chloride in methanol; dichloromethane; chloroform
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP624584 A1, 1994 ;
