3,4-二甲氧基苯乙酸合成路线 （共 159 条）
反应条件
thionyl chloride in benzene
参考文献
SmithKline Beckman Corporation
Patent: US4529604 A1, 1985 ;
US 4529604 A
反应条件
in 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran; N,N-dimethyl-formamide
参考文献
Beaulieu, Pierre Louis; Fazal, Gulrez; Gillard, James; Kukolj, George; Austel, Volkhard
Patent: US2002/65418 A1, 2002 ;
反应条件
T=150°C; 0.5 h; Microwave irradiation;
参考文献
Wu, Jianjun; Talwar, Dinesh; Johnston, Steven; Yan, Ming; Xiao, Jianliang
Angewandte Chemie - International Edition, 2013 , vol. 52, # 27 p. 6983 - 6987
Ross. Khim. Zh., 2013 , vol. 125, # 27 p. 7121 - 7125,5
反应条件
sodium hydroxide; thionyl chloride in methanol; dichloromethane; chloroform
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP624584 A1, 1994 ;
反应条件
1: (COCl)2; DMF / CH2Cl2 / 2 h / 20 °C 2: Na2CO3 / CH2Cl2; H2O / 2 h / 20 °C View Scheme
参考文献
Padwa, Albert; Beall, L. Scott; Heidelbaugh, Todd M.; Liu, Bing; Sheehan, Scott M.
Journal of Organic Chemistry, 2000 , vol. 65, # 9 p. 2684 - 2695
反应条件
1: sulfuric acid / dichloromethane / Reflux 2: perchloric acid / water / 1.25 h / 0 - 20 °C / Inert atmosphere 3: ammonium hydroxide / water / 1 h / 20 °C View Scheme
参考文献
US2012/214837 A1, ;
US 20120214837 A1
反应条件
1: 84 percent / thionyl chloride 2: Et3N / hexane / 1.) rt, 4 h 2.) 60 deg C, 0.5 h View Scheme
参考文献
Law, Kock-Yee; Bailey, F. Court
Journal of Organic Chemistry, 1992 , vol. 57, # 12 p. 3278 - 3286
反应条件
1.1: 86 percent / ICl / CH2Cl2; acetic acid 2.1: 92 percent / SOCl2 / 20 °C 3.1: 96 percent / Et3N / [PdCl2(PPh3)2] / acetonitrile / 6 h / Heating 4.1: 100 percent / H2 / 10 percent Pd/C / ethanol / 2585.74 Torr 5.1: KO-tert-Bu / diethyl ether / 0.5 h 5.2: 62 percent / LiCl; HCl; H2O / dimethylsulfoxide / 5 h / 125 °C View Scheme
参考文献
Kanao, Munefumi; Hashizume, Takeshi; Ichikawa, Yoshifumi; Irie, Kiyoshi; Isoda, Sumiro
Journal of Medicinal Chemistry, 1982 , vol. 25, # 11 p. 1358 - 1363
反应条件
hydrogenchloride; acetic acid 1 h; Heating;
参考文献
Weimar; Van Angerer; Wiegrebe
Archiv der Pharmazie, 1991 , vol. 324, # 8 p. 509 - 518
参考文献
Nimgirawath, S.; Srikirin, Y.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 3 p. 272 - 273
