3,4-二甲氧基苯乙酸合成路线 （共 159 条）
反应条件
1: 80 percent / triethylamine, 1,3-dicyclohexylcarbodiimide / CH2Cl2 / 16 h / Ambient temperature
2: tert-butyl hypochlorite / diethyl ether / 0.33 h / 0 °C
3: 73 percent / Ag2CO3, trifluoroacetic acid / 0.5 h / 0 °C
4: 88 percent / H2 / 10percent Pd/C / methanol
View Scheme
参考文献
Kawase, Masami; Kitamura, Takahiro; Kikugawa, Yasuo
Journal of Organic Chemistry, 1989 , vol. 54, # 14 p. 3394 - 3403
反应条件
pyridine
Perkin-Oglialoro reaction; 12 h; Reflux;
参考文献
Garazd; Ogorodniichuk; Khilya
Chemistry of Natural Compounds, 2009 , vol. 45, # 2 p. 158 - 163
反应条件
1: 92 percent / 2 h / 190 - 210 °C
2: phosphoryl chloride / toluene / 3 h / Heating
3: 71 percent / sodium borohydride / 19 h / Ambient temperature
4: 51 percent / benzene / 48 h / Heating
5: 86 percent / acetonitrile / 48 h / Ambient temperature
View Scheme
参考文献
Stenlake; Waigh; Dewar; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 6 p. 515 - 524
反应条件
1: thionyl chloride / 5 h / Ambient temperature
2: 1 h
3: HNO3 / acetic acid / 1 h / 0 °C
View Scheme
参考文献
Swenton,J.S.; Bonke,B.R.; Chen,C-P.
Journal of Organic Chemistry, 1989 , vol. 54, p. 51
参考文献
Shepard et al.
Journal of the American Chemical Society, 1952 , vol. 74, p. 4611,4614
反应条件
Fe(3+)-K-10 montmorillonite clay in chloroform
7.5 h; Heating;
参考文献
Srinivas; Das, Biswanath
Journal of Organic Chemistry, 2003 , vol. 68, # 3 p. 1165 - 1167
反应条件
1: (3,4-dimethoxyphenyl)-acetic acid With 4-(N,N-dimethlyamino)pyridine; polystyrene resin-CH2NHC(O)C6H4-p-CH2OH; dacarbazine in dichloromethane
T=20°C; 3 h;
2: benzoyl chloride With tin(IV) chloride in dichloromethane
T=20°C; Friedel-Crafts acylation; 12 h;
3: With hydrazine in ethanol
24 h; Heating;
参考文献
Bevacqua, Francesca; Basso, Andrea; Gitto, Rosaria; Bradley, Mark; Chimirri, Alba
Tetrahedron Letters, 2001 , vol. 42, # 43 p. 7683 - 7685
反应条件
1.1: sulfuric acid / Reflux
2.1: tin(ll) chloride / 20 °C
3.1: hydrazine hydrate / ethanol / 3 h / 150 °C
3.2: 0.5 h / Reflux
View Scheme
参考文献
Bihel, Frederic J.J.; Justiniano, Helene; Schmitt, Martine; Hellal, Malik; Ibrahim, Mohamed A.; Lugnier, Claire; Bourguignon, Jean-Jacques
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 21 p. 6567 - 6572
反应条件
1: 95 percent / Br2 / CH2Cl2
2: SOCl2 / 1 h / Heating
3: 6.38 g / aq. Na2CO3 / diethyl ether / 6 h / 20 °C
4: 76 percent / POCl3 / acetonitrile / 4 h / Heating
View Scheme
参考文献
Stenlake; Waigh; Dewar; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 6 p. 515 - 524
