3,4-二甲氧基苯乙酸合成路线 （共 159 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C; Reflux;
参考文献
Zhao, Yu-Ming; Gu, Peiming; Tu, Yong-Qiang; Zhang, Hai-Jun; Zhang, Qing-Wei; Fan, Chun-An
Journal of Organic Chemistry, 2010 , vol. 75, # 15 p. 5289 - 5295
反应条件
1: 92 percent / 2 h / 190 - 210 °C 2: phosphoryl chloride / toluene / 3 h / Heating 3: 71 percent / sodium borohydride / 19 h / Ambient temperature 4: 51 percent / benzene / 48 h / Heating 5: 85 percent / acetonitrile / 48 h / Ambient temperature View Scheme
参考文献
Stenlake; Waigh; Dewar; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 6 p. 515 - 524
反应条件
1: 81 percent / thionyl chloride / CH2Cl2 / 1 h / Heating 2: triethylamine / CH2Cl2 / 1 h / Ambient temperature 3: 75 percent / glacial acetic acid, conc. HCl / 17 h / Ambient temperature View Scheme
参考文献
Reiffen; Eberlein; Muller; Psiorz; Noll; Heider; Lillie; Kobinger; Luger
Journal of Medicinal Chemistry, 1990 , vol. 33, # 5 p. 1496 - 1504
反应条件
1: (COCl)2; DMF / CH2Cl2 / 2 h / 20 °C 2: Na2CO3 / CH2Cl2; H2O / 2 h / 20 °C 3: 98 percent / POCl3 / dimethylformamide / 3 h / 20 °C View Scheme
参考文献
Kaur, Jaskiran; Ghosh, Narendra Nath; Talwar, Anita; Chandra, Ramesh
Chemical and pharmaceutical bulletin, 2002 , vol. 50, # 9 p. 1223 - 1228
反应条件
PPA in dichloromethane T=80°C; 72 h;
参考文献
Venkov, Atanas P.; Ivanov, Ilian I.
Tetrahedron, 1996 , vol. 52, # 37 p. 12299 - 12308
反应条件
trichlorophosphate in toluene T=20 - 120°C; Bischler-Napieralski reaction; 3.5 h;
参考文献
Gan, Haifeng; Lu, Yunyu; Huang, Yue; Ni, Lijun; Xu, Jinyi; Yao, Hequan; Wu, Xiaoming
Tetrahedron Letters, 2011 , vol. 52, # 12 p. 1320 - 1324
反应条件
1.1: dicyclohexyl-carbodiimide; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 2 h / 20 °C 2.1: 4-(N,N-dimethlyamino)pyridine; boron trifluoride diethyl etherate; B2H6*Me2S / 3 h / 70 °C 3.1: dicyclohexyl-carbodiimide; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 2 h / 20 °C 4.1: trichlorophosphate / benzene / 7 h / |Reflux 4.2: 3 h / 20 °C / |Inert atmosphere 5.1: boron tribromide / dichloromethane / 2 h / -78 - 20 °C View Scheme
参考文献
Pesnot, Thomas; Gershater, Markus C.; Ward, John M.; Hailes, Helen C.
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 16 p. 2997 - 3008
反应条件
2: POCl3 / toluene 3: Pd/Al2O3 / 1,2,3,4-tetrahydro-naphthalene View Scheme
参考文献
Wu, Jianjun; Talwar, Dinesh; Johnston, Steven; Yan, Ming; Xiao, Jianliang
Angewandte Chemie - International Edition, 2013 , vol. 52, # 27 p. 6983 - 6987
Ross. Khim. Zh., 2013 , vol. 125, # 27 p. 7121 - 7125,5
反应条件
in N,N-dimethyl-formamide; toluene
参考文献
McNeilab, Inc.
Patent: US4742068 A1, 1988 ;
反应条件
oxalyl dichloride; ammonia 1.) toluene, DMF, RT, 17 h, 2.) 4 h; Yield given. Multistep reaction;
参考文献
Kindler; Peschke
Archiv der Pharmazie (Weinheim, Germany), 1933 , vol. 271, p. 431,435
