N-甲基-N-羟乙基苯胺合成路线 （共 41 条）
反应条件
N-ethyl-N,N-diisopropylamine in acetonitrile T=70°C; 16 h;
参考文献
CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER; UNIVERSITY OF CINCINNATI; Merino, Edward J.; Mulloy, James C.; Li, Guorui; Bell-Horwath, Tiffany
Patent: US2013/230542 A1, 2013 ;
Location in patent: Paragraph 0122 ;
参考文献
PHARMACIA CORPORATION
Patent: WO2003/99769 A1, 2003 ;
Location in patent: Page 47 ;
反应条件
in acetonitrile Heating;
参考文献
Arunkumar, Easwaran; Chithra, Parayali; Ajayaghosh, Ayyappanpillai
Journal of the American Chemical Society, 2004 , vol. 126, # 21 p. 6590 - 6598
反应条件
sodium hydrogencarbonate in methanol T=20°C; Methylation; 90 h;
参考文献
Kostas, Ioannis D.; Screttas, Constantinos G.
Journal of Organometallic Chemistry, 1999 , vol. 585, # 1 p. 1 - 6
反应条件
tert.-butylhydroperoxide; titanium(III) chloride T=20°C; 0.5 h; Acidic aq. solutionInert atmosphere;
参考文献
Clerici, Angelo; Ghilardi, Alessandra; Pastori, Nadia; Punta, Carlo; Porta, Ombretta
Organic Letters, 2008 , vol. 10, # 21 p. 5063 - 5066
反应条件
[Ru2(p-PriC6H4Me)2(μ-Cl)Cl]2; bis[2-(diphenylphosphino)phenyl] ether in toluene T=20°C; Inert atmosphereReflux;
参考文献
Journal of the American Chemical Society, , vol. 131, p. 1766 - 1774
反应条件
methanesulfonic acid; hydrogen; [Ru(acac)3]; 1,1,1-tris (diphenylphosphinomethyl)ethane in tetrahydrofuran T=140°C; 24 h; AutoclaveInert atmosphere;
参考文献
Li, Yuehui; Sorribes, Ivan; Yan, Tao; Junge, Kathrin; Beller, Matthias
Angewandte Chemie - International Edition, 2013 , vol. 52, # 46 p. 12156 - 12160
Angew. Chem., 2013 , vol. 125, # 46 p. 12378 - 12382,5
反应条件
Na-Y zeolite in triglyme (triethylene glycol dimethyl ether) 6 h; Heating;
参考文献
Shivarkar, Anandkumar B.; Gupte, Sunil P.; Chaudhari, Raghunath V.
Synlett, 2006 , # 9 p. 1374 - 1378
反应条件
tert.-butylhydroperoxide; titanium(III) chloride in water T=20°C;
参考文献
Spaccini, Raffaele; Ghilardi, Alessandra; Pastori, Nadia; Clerici, Angelo; Punta, Carlo; Porta, Ombretta
Tetrahedron, 2010 , vol. 66, # 11 p. 2044 - 2052
反应条件
1: 93 percent / Na2CO3 / ethanol / Heating 2: lithium aluminium hydride / tetrahydrofuran / 4 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 61, # 41 p. 9822 - 9826
