反应条件
1: triethylamine; trimethylsilylazide / dichloromethane; acetic acid / 0 - 20 °C 2: palladium 10 on activated carbon; hydrogen / acetic acid / 20 °C / 724.03 Torr / |Inert atmosphere 3: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C 4: hydrogenchloride / dichloromethane; 1,4-dioxane / 1 h / 0 °C View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; BHIDE, Rajeev S.; DUNCIA, John V.; HYNES, John; NAIR, Satheesh K.; PITTS, William J.; KUMAR, Sreekantha R.; GARDNER, Daniel S.; MURUGESAN, Natesan; PAIDI, Venkatram Reddy; SANTELLA, Joseph B.; SISTLA, Ramesh; WU, Hong
Patent: WO2014/74675 A1, 2014 ;