1: 1-methyl-1H-pyrazole With n-butyllithium in tetrahydrofuran T=0 - 20°C; 2: 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in tetrahydrofuran T=-78°C;
1: With n-butyllithium in tetrahydrofuran T=-78°C; 1.5 h; 2: With tri-isopropoxy-borane in tetrahydrofuran T=-78 - 0°C; 3: With hydrogenchloride; water in tetrahydrofuran pH=6;
参考文献
ARENA PHARMACEUTICALS, INC.
Patent: WO2005/12254 A1, 2005 ;
Location in patent: Page/Page column 101 ;
WO 2005/012254 A1
1: 1-methyl-1H-pyrazole With n-butyllithium in tetrahydrofuran T=-78°C; 1.5 h; 2: tri-isopropoxy-borane in tetrahydrofuran T=20°C;
参考文献
PFIZER INC.; HELAL, Christopher J.; CHAPPIE, Thomas Allen; HUMPHREY, John M.
Patent: WO2012/168817 A1, 2012 ;
Location in patent: Page/Page column 44-45 ;
WO 2012/168817 A1
