2,4-二甲基咪唑合成路线

Busby, Reginald E.; Khan, Mohammad A.; Khan, Mohammad R.; Parrick, John; Shaw, C. J. Granville; Iqbal, Mohammad
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1427 - 1430

930-62-12,4-二甲基咪唑+

67-66-3氯仿

4472-45-12-氨基-4-氯-6-甲基嘧啶+

95-89-63-氯-2,5-二甲基吡嗪+

75712-74-24-氯-2,5-二甲基嘧啶+

75712-73-1(9CI)-5-氯-2,4-二甲基嘧啶

参考文献

Busby, Reginald E.; Khan, Mohammad A.; Khan, Mohammad R.; Parrick, John; Shaw, C. J. Granville; Iqbal, Mohammad
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1427 - 1430

930-62-12,4-二甲基咪唑+

67-66-3氯仿

4472-45-12-氨基-4-氯-6-甲基嘧啶+

95-89-63-氯-2,5-二甲基吡嗪+

38557-72-12-氯-1-二甲基吡嗪+

75712-73-1(9CI)-5-氯-2,4-二甲基嘧啶

参考文献

Busby, Reginald E.; Khan, Mohammad A.; Khan, Mohammad R.; Parrick, John; Shaw, C. J. Granville; Iqbal, Mohammad
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1427 - 1430

930-62-12,4-二甲基咪唑+

870-24-62-氯乙胺盐酸盐

279237-85-3[2-(2,4-二甲基咪唑-1-基)乙基]胺

参考文献

ACTELION PHARMACEUTICALS LTD
Patent: WO2008/78291 A1, 2008 ;
Location in patent: Page/Page column 72-73 ;
WO 2008/078291 A1

930-62-12,4-二甲基咪唑+

870-24-62-氯乙胺盐酸盐

279237-85-3[2-(2,4-二甲基咪唑-1-基)乙基]胺+

279236-79-2

参考文献

SCHERING CORPORATION
Patent: WO2007/84498 A1, 2007 ;
Location in patent: Page/Page column 189 ;

930-62-12,4-二甲基咪唑+

67-66-3氯仿

4472-45-12-氨基-4-氯-6-甲基嘧啶+

95-89-63-氯-2,5-二甲基吡嗪+

75712-74-24-氯-2,5-二甲基嘧啶+

75712-73-1(9CI)-5-氯-2,4-二甲基嘧啶

参考文献

Busby, Reginald E.; Khan, Mohammad A.; Khan, Mohammad R.; Parrick, John; Shaw, C. J. Granville; Iqbal, Mohammad
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1427 - 1430