2-(叔丁氧基羰基氨基)-4-(甲基硫代)丁酸合成路线 （共 10 条）
反应条件
2: NH2OH 3: TFA / various solvent(s) View Scheme
参考文献
Lee, Jeewoo; Kang, Mee Kyoung; Chun, Moon Woo; Jo, Yeong Joon; Kwak, Jin Hwan; Kim, Sunghoon
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 24 p. 3511 - 3514
反应条件
1: EDC / pyridine; CH2Cl2 2: LiAlH4 / tetrahydrofuran View Scheme
参考文献
Hulme, Christopher; Ma, Liang; Romano, Joseph; Morrissette, Matthew
Tetrahedron Letters, 1999 , vol. 40, # 45 p. 7925 - 7928
反应条件
sodium carbonate in 1,4-dioxane; water
T=0 - 20°C;
参考文献
Picha, Jan; Vanek, Vaclav; Budesinsky, Milos; Mladkova, Jana; Garrow, Timothy A.; Jiracek, Jiri
European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 256 - 275
反应条件
triethylamine in methanol
T=20°C; 0.5 h;
参考文献
Hioki, Kazuhito; Kinugasa, Mizuho; Kishimoto, Michiko; Fujiwara, Miho; Tani, Shohei; Kunishima, Munetaka
Synthesis, 2006 , # 12 p. 1931 - 1933
反应条件
sodium hydroxide; potassium hydrogensulfate in 1,4-dioxane; ethyl acetate
参考文献
Glaxo Wellcome Inc.
Patent: US5994344 A1, 1999 ;
反应条件
triethylamine in 1,4-dioxane; water
0.166667 h; Ambient temperature;
参考文献
Kim, Sunggak; Chang, Heung
Journal of the Chemical Society, Chemical Communications, 1983 , # 22 p. 1357 - 1358
参考文献
University of Pittsburgh
Patent: US2002/193596 A1, 2002 ;
反应条件
toluene
nachfolgendes Erwaermen des Reaktionsprodukts mit tert-Butylalkohol und anschliessendes Hydrolysieren;
参考文献
McKay; Albertson
Journal of the American Chemical Society, 1957 , vol. 79, p. 4686,4689
反应条件
sodium carbonate; tert-butyl alcohol
参考文献
Anderson; McGregor
Journal of the American Chemical Society, 1957 , vol. 79, p. 6180,6181
反应条件
1,2-dichloro-ethane in dichloromethane; ethyl acetate
参考文献
Merck and Co., Inc.
Patent: US5703241 A1, 1997 ;
US 5703241 A
