4-氨基喹啉-3-羧酸乙酯合成路线 （共 5 条）
反应条件
1: With potassium hydroxide; ethanol; water 1 h; Heating / reflux; 2: With hydrogenchloride in water pH=~ 6.5 - 7;
参考文献
AVANIR PHARMACEUTICALS
Patent: WO2005/123686 A1, 2005 ;
Location in patent: Page/Page column 88-89 ;
WO 2005/123686 A1
反应条件
ammonia in toluene
T=120 - 125°C; 4 h;
参考文献
Marecki; Bambury
Journal of Pharmaceutical Sciences, 1984 , vol. 73, # 8 p. 1141 - 1143
反应条件
tin(IV) chloride in toluene
5 h; Heating;
参考文献
Chattopadhyay, Shital K.; Dey, Rajat; Biswas, Suman
Synthesis, 2005 , # 7 art. no. T10804SS, p. 1083 - 1086
反应条件
tin(IV) chloride in toluene
5 h; Heating;
参考文献
Chattopadhyay, Shital K.; Dey, Rajat; Biswas, Suman
Synthesis, 2005 , # 7 art. no. T10804SS, p. 1083 - 1086
反应条件
1: 82 percent / p-TsOH / Heating
2: 21 percent / SnCl4 / toluene / 5 h / Heating
View Scheme
参考文献
Chattopadhyay, Shital K.; Dey, Rajat; Biswas, Suman
Synthesis, 2005 , # 7 art. no. T10804SS, p. 1083 - 1086
