(R)-4-boc-1-cbz-2-羟基甲基哌嗪合成路线 (共 1 条)
反应条件
1: With 4-methyl-morpholine; isobutyl chloroformate in ethylene glycol dimethyl ether
T=0°C; 0.333333 h;
2: With sodium tetrahydroborate in ethylene glycol dimethyl ether; water
T=20°C;
参考文献
ASTRAZENECA AB
Patent: WO2007/37743 A1, 2007 ;
Location in patent: Page/Page column 47 ;
WO 2007/037743 A1