2-(6-氯吡嗪-2-基)丙二酸二甲酯盐酸盐合成路线 （共 2 条）
反应条件
1: With sodium hydroxide; water in tetrahydrofuran T=10°C; 24 h; Heating / reflux; 2: With hydrogenchloride in water T=20 - 25°C;
参考文献
ASTRAZENECA AB
Patent: WO2007/35154 A1, 2007 ;
Location in patent: Page/Page column 28-29 ;
WO 2007/035154 A1
反应条件
sodium hydride in tetrahydrofuran
T=0°C; 18 h; Heating / reflux;
参考文献
ASTRAZENECA AB
Patent: WO2007/35153 A1, 2007 ;
Location in patent: Page/Page column 4-5 ;
