3,5-二甲基环戊-2-烯-1-酮合成路线 （共 15 条）
反应条件
1: NH2OH*HCl; NaOAc / methanol; H2O / 2 h / Heating 2: pyridine / 1 h / 20 °C 3: HCl / methanol / 12 h / Heating View Scheme
参考文献
Kawanaka, Yasufumi; Kobayashi, Kaoru; Kusuda, Shinya; Tatsumi, Tadashi; Murota, Masanori; Nishiyama, Toshihiko; Hisaichi, Katsuya; Fujii, Atsuko; Hirai, Keisuke; Naka, Masao; Komeno, Masaharu; Nakai, Hisao; Toda, Masaaki
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 17 p. 2291 - 2294
反应条件
lithium aluminium tetrahydride in diethyl ether
参考文献
Mironov,V.A.; Elizarova,A.N.
J. Gen. Chem. USSR (Engl. Transl.), 1962 , vol. 32, # 8 p. 2731 - 2738,2688 - 2694
反应条件
hydrogen bromide
T=100°C; 0.25 h;
参考文献
Santelli-Rouvier, Christiane
Tetrahedron, 1981 , vol. 37, # 24 p. 4195 - 4200
反应条件
anhydrous lithium acetate; lithium; acetic acid
0.25 h; Heating;
参考文献
Ponaras, Anthony A.; Zaim, Oemer; Pazo, Yessica; Ohannesian, Lena
Journal of Organic Chemistry, 1988 , vol. 53, # 5 p. 1110 - 1112
反应条件
1: 3-methylcyclopent-2-en-1-one With N,N,N',N',N'',N''-hexamethylphosphoric triamide; lithium diisopropyl amide in tetrahydrofuran
T=-78°C; 0.5 h;
2: methyl halide in tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide
T=-78 - 20°C; 13 h;
参考文献
Tanyeli, Cihangir; Iyiguen, Cigdem
Tetrahedron, 2003 , vol. 59, # 36 p. 7135 - 7139
反应条件
potassium hydroxide in water
T=100°C; 2 h; Yield given. Title compound not separated from byproducts;
参考文献
Trani; Bellasio
Farmaco, Edizione Scientifica, 1983 , vol. 38, # 12 p. 940 - 949
反应条件
hydrogen bromide
T=100°C; 2 h;
参考文献
Santelli-Rouvier, Christiane
Tetrahedron, 1981 , vol. 37, # 24 p. 4195 - 4200
反应条件
sodium hydroxide in ethanol
12 h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Ahlbrecht, Hubertus; Daacke, Axel von
Synthesis, 1987 , # 1 p. 24 - 28
反应条件
hydrogen bromide
T=100°C;
参考文献
Hiyama, Tamejiro; Shinoda, Masaki; Tsukanaka, Masao; Nozaki, Hitosi
Bulletin of the Chemical Society of Japan, 1980 , vol. 53, # 4 p. 1010 - 1014
反应条件
methanol; sulfuric acid; mercuric sulphate
参考文献
Nasarow et al.
Zhurnal Obshchei Khimii, 1958 , vol. 28, p. 2746,2751; engl. Ausg. S. 2771, 2776
