反应条件
1: 1.) O3, NaHCO3, 2.) Et3N / 1.) CH2Cl2, MeOH, 2.) CH2Cl2, a) 0 deg C, 15 min, b) RT, 4 h
2: 1.) t-BuOK / 1.) THF, DMSO, -10 deg C, 30 min, 2.) THF, -10 deg C
3: LiAlH4 / tetrahydrofuran / 2 h / 0 °C
4: (COCl)2, DMSO
5: 1.) t-BuOK / 1.) THF, 0 deg C, 20 min, 2.) THF, 50 min, RT
6: H2 / 10percent Pd/C / ethanol
View Scheme
参考文献
Kiuchi, Fumiyuki; Nakamura, Norio; Saito, Makiko; Komagome, Kazue; Hiramatsu, Hirokuni; Takimoto, Noriaki; Akao, Nobuaki; Kondo, Kaoru; Tsuda, Yoshisuke
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 4 p. 685 - 696
