N-(甲氧甲基)-N-(三甲基硅甲基)苄胺合成路线 （共 42 条）
反应条件
1: in water T=0°C; 2: With potassium carbonate in water T=20°C; 2 h;
参考文献
CELON PHARMA S.A.; MOSZCZYNSKI-PETKOWSKI, Rafal; BOJARSKI, Lukasz; MAJER, Jakub; WIECZOREK, Maciej; DUBIEL, Krzysztof; LAMPARSKA-PRZYBYSZ, Monika
Patent: WO2014/24125 A1, 2014 ;
Location in patent: Page/Page column 24-25 ;
参考文献
Shi, Jin; Stover, James S.; Whitby, Landon R.; Vogt, Peter K.; Boger, Dale L.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 21 p. 6038 - 6041
反应条件
1: formaldehyd; N-benzyl-N-[(trimethylsilyl)methyl]amine T=0°C; 0.166667 h; 2: methanol With potassium carbonate T=20°C; 73 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2006/61711 A1, 2006 ;
Location in patent: Page/Page column 17 ;
反应条件
formaldehyd; potassium carbonate in methanol
参考文献
Bristol-Myers Squibb Pharma Company
Patent: EP934265 B1, 2003 ;
反应条件
n-butyllithium in tetrahydrofuran; hexane 1.) -70 deg C; 2.) 3 h, -70 deg C;
参考文献
Terao, Yoshiyasu; Kotaki, Hiromi; Imai, Nobuyuki; Achiwa, Kazuo
Chemical & Pharmaceutical Bulletin, 1985 , vol. 33, # 7 p. 2762 - 2766
反应条件
in tetrahydrofuran; hexane
反应条件
1: 0.33 h / Reflux; neat (no solvent) 2: potassium carbonate / water / 16 h / 0 - 25 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 133, # 26 p. 10184 - 10194
反应条件
1: benzylamine; chloromethyl-trimethyl-silane Reflux; 2: methanol; formaldehyd With potassium carbonate in water
参考文献
Bioorganic and Medicinal Chemistry, , vol. 18, # 21 p. 7611 - 7620
反应条件
in water T=0 - 15°C; 4 h;
参考文献
Chemistry of Heterocyclic Compounds, , vol. 43, # 1 p. 34 - 40
反应条件
tris(pentafluorophenyl)-borane in dichloromethane 1.5 h;
参考文献
Srihari, Pabbaraja; Yaragorla, Srinivasa Rao; Basu, Debjit; Chandrasekhar, Srivari
Synthesis, 2006 , # 16 p. 2646 - 2648
