N-(甲氧甲基)-N-(三甲基硅甲基)苄胺合成路线 （共 42 条）
反应条件
trifluoroacetic acid in toluene T=20°C; 2 h;
参考文献
Cumbre Inc.
Patent: US2006/19985 A1, 2006 ;
Location in patent: Page/Page column 25 ;
反应条件
trifluoroacetic acid in dichloromethane T=20 - 25°C; 5 h;
参考文献
Basha, Anwer; Bunnelle, William H.; Dart, Michael J.; Gallagher, Megan E.; Ji, Jianguo; Li, Tao; Pace, Jennifer M.; Ryther, Keith B.; Tietje, Karin R.; Mortell, Kathleen H.; Nersesian, Diana L.; Schrimpf, Michael R.
Patent: US2005/101602 A1, 2005 ;
Location in patent: Page/Page column 34-35 ;
反应条件
trifluoroacetic acid in dichloromethane T=25°C; 48 h;
参考文献
Bucsh, Ruth A.; Domagala, John M.; Laborde, Edgardo; Sesnie, Josephine C.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 26 p. 4139 - 4151
反应条件
LiF in acetonitrile T=20°C; 24 h;
参考文献
Grafton, Mark; Mansfield, Andrew C.; Fray, M. Jonathan
Tetrahedron Letters, 2010 , vol. 51, # 7 p. 1026 - 1029
反应条件
trifluoroacetic acid in dichloromethane 2 h; Ambient temperature;
参考文献
Jenkins; Wadsworth; Bromidge; Orlek; Wyman; Riley; Hawkins
Journal of Medicinal Chemistry, 1992 , vol. 35, # 13 p. 2392 - 2406
反应条件
1: in dichloromethane
T=-5°C; 0.5 h;
2: With trifluoroacetic acid in dichloromethane
6 h;
参考文献
Kurkin; Sumtsova; Yurovskaya
Chemistry of Heterocyclic Compounds, 2007 , vol. 43, # 1 p. 34 - 40
反应条件
trifluoroacetic acid
T=20°C; 12 h;
参考文献
Whitten, Jeffrey P.; Pierre, Fabrice; Regan, Collin; Schwaebe, Michael; Yiannikouros, George Petros; Jung, Michael
Patent: US2006/63761 A1, 2006 ;
Location in patent: Page/Page column 6; 13-14 ;
反应条件
1.1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C / Cooling with water
1.2: 67 h / 20 °C
1.3: 1 h / 5 °C / pH 1.5
2.1: hydrogen / [Ru(OAc)2((S)-2-Furyl-MeOBIPHEP)] / methanol / 20 h / 30 °C / 30003 Torr / Inert atmosphere
3.1: sulfuric acid / 19 h / 60 °C
3.2: 0 °C / pH 9
4.1: sodium methylate / methanol / 116 h / 20 °C
4.2: 19 h / 60 °C / pH 1
4.3: 0 °C / pH 9
View Scheme
参考文献
Knust, Henner; Koblet, Andreas; Nettekoven, Matthias; Ratni, Hasane; Riemer, Claus; Vifian, Walter
Patent: US2011/144081 A1, 2011 ;
US 20110144081 A1
反应条件
trifluoroacetic acid in dichloromethane
T=0 - 20°C;
参考文献
ATHERSYS, INC.
Patent: WO2006/28961 A2, 2006 ;
Location in patent: Page/Page column 72-73 ;
WO 2006/028961 A2
反应条件
1: With trifluoroacetic acid in dichloromethane
T=0 - 20°C; 16.75 h;
2: With sodium hydrogencarbonate in dichloromethane; water
参考文献
TARGACEPT, INC.
Patent: WO2008/57938 A1, 2008 ;
Location in patent: Page/Page column 29-30 ;
WO 2008/057938 A1
